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Development of a SFTSV DNA vaccine that confers complete protection against lethal infection in ferrets

Author

Listed:
  • Jeong-Eun Kwak

    (Korea Advanced Institute of Science and Technology)

  • Young-Il Kim

    (Chungbuk National University)

  • Su-Jin Park

    (Chungbuk National University)

  • Min-Ah Yu

    (Chungbuk National University)

  • Hyeok-Il Kwon

    (Chungbuk National University)

  • Sukyeong Eo

    (Korea Advanced Institute of Science and Technology)

  • Tae-Shin Kim

    (Korea Advanced Institute of Science and Technology)

  • Joon Seok

    (Korea Advanced Institute of Science and Technology)

  • Won-Suk Choi

    (Chungbuk National University)

  • Ju Hwan Jeong

    (Chungbuk National University)

  • Hyojin Lee

    (GeneOne Life Science, Inc.)

  • Youngran Cho

    (GeneOne Life Science, Inc.)

  • Jin Ah Kwon

    (GeneOne Life Science, Inc.)

  • Moonsup Jeong

    (GeneOne Life Science, Inc.)

  • Joel N. Maslow

    (GeneOne Life Science, Inc.)

  • Yong-Eun Kim

    (Chungnam National University)

  • Haili Jeon

    (Chungnam National University)

  • Kee K. Kim

    (Chungnam National University)

  • Eui-Cheol Shin

    (Korea Advanced Institute of Science and Technology
    Korea Advanced Institute of Science and Technology)

  • Min-Suk Song

    (Chungbuk National University)

  • Jae U. Jung

    (University of Southern California)

  • Young Ki Choi

    (Chungbuk National University)

  • Su-Hyung Park

    (Korea Advanced Institute of Science and Technology
    Korea Advanced Institute of Science and Technology)

Abstract

Although the incidence of severe fever with thrombocytopenia syndrome virus (SFTSV) infection has increased from its discovery with a mortality rate of 10–20%, no effective vaccines are currently available. Here we describe the development of a SFTSV DNA vaccine, its immunogenicity, and its protective efficacy. Vaccine candidates induce both a neutralizing antibody response and multifunctional SFTSV-specific T cell response in mice and ferrets. When the vaccine efficacy is investigated in aged-ferrets that recapitulate fatal clinical symptoms, vaccinated ferrets are completely protected from lethal SFTSV challenge without developing any clinical signs. A serum transfer study reveals that anti-envelope antibodies play an important role in protective immunity. Our results suggest that Gn/Gc may be the most effective antigens for inducing protective immunity and non-envelope-specific T cell responses also can contribute to protection against SFTSV infection. This study provides important insights into the development of an effective vaccine, as well as corresponding immune parameters, to control SFTSV infection.

Suggested Citation

  • Jeong-Eun Kwak & Young-Il Kim & Su-Jin Park & Min-Ah Yu & Hyeok-Il Kwon & Sukyeong Eo & Tae-Shin Kim & Joon Seok & Won-Suk Choi & Ju Hwan Jeong & Hyojin Lee & Youngran Cho & Jin Ah Kwon & Moonsup Jeon, 2019. "Development of a SFTSV DNA vaccine that confers complete protection against lethal infection in ferrets," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11815-4
    DOI: 10.1038/s41467-019-11815-4
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    Cited by:

    1. Xuanxiu Ren & Jiawen Sun & Wenhua Kuang & Feiyang Yu & Bingjie Wang & Yong Wang & Wei Deng & Zhao Xu & Shangyu Yang & Hualin Wang & Yangbo Hu & Zengqin Deng & Yun-Jia Ning & Haiyan Zhao, 2024. "A broadly protective antibody targeting glycoprotein Gn inhibits severe fever with thrombocytopenia syndrome virus infection," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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