IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-11754-0.html
   My bibliography  Save this article

ZIKV infection induces robust Th1-like Tfh cell and long-term protective antibody responses in immunocompetent mice

Author

Listed:
  • Huabin Liang

    (Institut Pasteur of Shanghai, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Jinyi Tang

    (Institut Pasteur of Shanghai, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Zhihua Liu

    (Institut Pasteur of Shanghai, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yuanhua Liu

    (Institut Pasteur of Shanghai, Chinese Academy of Sciences)

  • Yuanyuan Huang

    (Institut Pasteur of Shanghai, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yongfen Xu

    (Institut Pasteur of Shanghai, Chinese Academy of Sciences)

  • Pei Hao

    (Institut Pasteur of Shanghai, Chinese Academy of Sciences)

  • Zhinan Yin

    (Jinan University)

  • Jin Zhong

    (Institut Pasteur of Shanghai, Chinese Academy of Sciences)

  • Lilin Ye

    (Third Military Medical University)

  • Xia Jin

    (Institut Pasteur of Shanghai, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Haikun Wang

    (Institut Pasteur of Shanghai, Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

Abstract

Induction of long-lived antibody responses during infection or vaccination is often essential for subsequent protection, but the relative contributions of T follicular helper (Tfh) cells and T helper 1 (Th1) cells for induction of antigen specific antibody responses to viruses are unclear. Here, we establish an acute Zika virus (ZIKV) infection model in immunocompetent mice, and show that ZIKV infection elicits robust Th1-like Tfh cell and protective antibody responses. While these Th1-like Tfh cells share phenotypic and transcriptomic profiles with both Tfh and Th1 cells, they also have unique surface markers and gene expression characteristics, and are dependent on T-bet for their development. Th1-like Tfh cells, but not Th1 cells, are essential for class switching of ZIKV-specific IgG2c antibodies and maintenance of long-term neutralizing antibody responses. Our study suggests that specific modulation of the Th1-like Tfh cell response during infection or vaccination may augment the induction of antiviral antibody response to ZIKV and other viruses.

Suggested Citation

  • Huabin Liang & Jinyi Tang & Zhihua Liu & Yuanhua Liu & Yuanyuan Huang & Yongfen Xu & Pei Hao & Zhinan Yin & Jin Zhong & Lilin Ye & Xia Jin & Haikun Wang, 2019. "ZIKV infection induces robust Th1-like Tfh cell and long-term protective antibody responses in immunocompetent mice," Nature Communications, Nature, vol. 10(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11754-0
    DOI: 10.1038/s41467-019-11754-0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-11754-0
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-11754-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11754-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.