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Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy

Author

Listed:
  • Tuying Yong

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Xiaoqiong Zhang

    (Huazhong University of Science and Technology)

  • Nana Bie

    (Huazhong University of Science and Technology)

  • Hongbo Zhang

    (Åbo Akademi University)

  • Xuting Zhang

    (Huazhong University of Science and Technology)

  • Fuying Li

    (Huazhong University of Science and Technology)

  • Abdul Hakeem

    (Huazhong University of Science and Technology)

  • Jun Hu

    (Huazhong University of Science and Technology)

  • Lu Gan

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Hélder A. Santos

    (University of Helsinki
    University of Helsinki)

  • Xiangliang Yang

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

Abstract

Developing biomimetic nanoparticles without loss of the integrity of proteins remains a major challenge in cancer chemotherapy. Here, we develop a biocompatible tumor-cell-exocytosed exosome-biomimetic porous silicon nanoparticles (PSiNPs) as drug carrier for targeted cancer chemotherapy. Exosome-sheathed doxorubicin-loaded PSiNPs (DOX@E-PSiNPs), generated by exocytosis of the endocytosed DOX-loaded PSiNPs from tumor cells, exhibit enhanced tumor accumulation, extravasation from blood vessels and penetration into deep tumor parenchyma following intravenous administration. In addition, DOX@E-PSiNPs, regardless of their origin, possess significant cellular uptake and cytotoxicity in both bulk cancer cells and cancer stem cells (CSCs). These properties endow DOX@E-PSiNPs with great in vivo enrichment in total tumor cells and side population cells with features of CSCs, resulting in anticancer activity and CSCs reduction in subcutaneous, orthotopic and metastatic tumor models. These results provide a proof-of-concept for the use of exosome-biomimetic nanoparticles exocytosed from tumor cells as a promising drug carrier for efficient cancer chemotherapy.

Suggested Citation

  • Tuying Yong & Xiaoqiong Zhang & Nana Bie & Hongbo Zhang & Xuting Zhang & Fuying Li & Abdul Hakeem & Jun Hu & Lu Gan & Hélder A. Santos & Xiangliang Yang, 2019. "Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy," Nature Communications, Nature, vol. 10(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11718-4
    DOI: 10.1038/s41467-019-11718-4
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