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Space Station conditions are selective but do not alter microbial characteristics relevant to human health

Author

Listed:
  • Maximilian Mora

    (Medical University of Graz, Department of Internal Medicine)

  • Lisa Wink

    (Medical University of Graz, Department of Internal Medicine)

  • Ines Kögler

    (Medical University of Graz, Department of Internal Medicine)

  • Alexander Mahnert

    (Medical University of Graz, Department of Internal Medicine)

  • Petra Rettberg

    (Research Group Astrobiology, Linder Höhe)

  • Petra Schwendner

    (University of Edinburgh, School of Physics and Astronomy)

  • René Demets

    (European Space Research and Technology Centre (ESTEC))

  • Charles Cockell

    (University of Edinburgh, School of Physics and Astronomy)

  • Tatiana Alekhova

    (Lomonosov Moscow State University, Biological Faculty)

  • Andreas Klingl

    (Department of Biology I)

  • Robert Krause

    (Medical University of Graz, Department of Internal Medicine
    BioTechMed Graz)

  • Anna Zolotariof

    (University of Edinburgh, School of Physics and Astronomy)

  • Alina Alexandrova

    (Lomonosov Moscow State University, Biological Faculty)

  • Christine Moissl-Eichinger

    (Medical University of Graz, Department of Internal Medicine
    BioTechMed Graz)

Abstract

The International Space Station (ISS) is a unique habitat for humans and microorganisms. Here, we report the results of the ISS experiment EXTREMOPHILES, including the analysis of microbial communities from several areas aboard at three time points. We assess microbial diversity, distribution, functional capacity and resistance profile using a combination of cultivation-independent analyses (amplicon and shot-gun sequencing) and cultivation-dependent analyses (physiological and genetic characterization of microbial isolates, antibiotic resistance tests, co-incubation experiments). We show that the ISS microbial communities are highly similar to those present in ground-based confined indoor environments and are subject to fluctuations, although a core microbiome persists over time and locations. The genomic and physiological features selected by ISS conditions do not appear to be directly relevant to human health, although adaptations towards biofilm formation and surface interactions were observed. Our results do not raise direct reason for concern with respect to crew health, but indicate a potential threat towards material integrity in moist areas.

Suggested Citation

  • Maximilian Mora & Lisa Wink & Ines Kögler & Alexander Mahnert & Petra Rettberg & Petra Schwendner & René Demets & Charles Cockell & Tatiana Alekhova & Andreas Klingl & Robert Krause & Anna Zolotariof , 2019. "Space Station conditions are selective but do not alter microbial characteristics relevant to human health," Nature Communications, Nature, vol. 10(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11682-z
    DOI: 10.1038/s41467-019-11682-z
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    Cited by:

    1. Eliah G. Overbey & Krista Ryon & JangKeun Kim & Braden T. Tierney & Remi Klotz & Veronica Ortiz & Sean Mullane & Julian C. Schmidt & Matthew MacKay & Namita Damle & Deena Najjar & Irina Matei & Laura , 2024. "Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA)," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Iris Irby & Jared T. Broddrick, 2024. "Microbial adaptation to spaceflight is correlated with bacteriophage-encoded functions," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

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