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Interplay of protein corona and immune cells controls blood residency of liposomes

Author

Listed:
  • Francesca Giulimondi

    (Sapienza University of Rome
    Istituto Italiano di Tecnologia, Center for Life Nano Science@Sapienza)

  • Luca Digiacomo

    (Sapienza University of Rome)

  • Daniela Pozzi

    (Sapienza University of Rome)

  • Sara Palchetti

    (Sapienza University of Rome)

  • Elisabetta Vulpis

    (Sapienza University of Rome)

  • Anna Laura Capriotti

    (Sapienza University of Rome)

  • Riccardo Zenezini Chiozzi

    (Sapienza University of Rome)

  • Aldo Laganà

    (Sapienza University of Rome)

  • Heinz Amenitsch

    (Graz University of Technology)

  • Laura Masuelli

    (Sapienza University of Rome)

  • Giovanna Peruzzi

    (Istituto Italiano di Tecnologia, Center for Life Nano Science@Sapienza)

  • Morteza Mahmoudi

    (Michigan State University)

  • Isabella Screpanti

    (Sapienza University of Rome)

  • Alessandra Zingoni

    (Sapienza University of Rome)

  • Giulio Caracciolo

    (Sapienza University of Rome)

Abstract

In vivo liposomes, like other types of nanoparticles, acquire a totally new ‘biological identity’ due to the formation of a biomolecular coating known as the protein corona that depends on and modifies the liposomes’ synthetic identity. The liposome–protein corona is a dynamic interface that regulates the interaction of liposomes with the physiological environment. Here we show that the biological identity of liposomes is clearly linked to their sequestration from peripheral blood mononuclear cells (PBMCs) of healthy donors that ultimately leads to removal from the bloodstream. Pre-coating liposomes with an artificial corona made of human plasma proteins drastically reduces capture by circulating leukocytes in whole blood and may be an effective strategy to enable prolonged circulation in vivo. We conclude with a critical assessment of the key concepts of liposome technology that need to be reviewed for its definitive clinical translation.

Suggested Citation

  • Francesca Giulimondi & Luca Digiacomo & Daniela Pozzi & Sara Palchetti & Elisabetta Vulpis & Anna Laura Capriotti & Riccardo Zenezini Chiozzi & Aldo Laganà & Heinz Amenitsch & Laura Masuelli & Giovann, 2019. "Interplay of protein corona and immune cells controls blood residency of liposomes," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11642-7
    DOI: 10.1038/s41467-019-11642-7
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    Cited by:

    1. Huimin Kong & Chunxiong Zheng & Ke Yi & Rachel L. Mintz & Yeh-Hsing Lao & Yu Tao & Mingqiang Li, 2024. "An antifouling membrane-fusogenic liposome for effective intracellular delivery in vivo," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Ali Akbar Ashkarran & Hassan Gharibi & Elizabeth Voke & Markita P. Landry & Amir Ata Saei & Morteza Mahmoudi, 2022. "Measurements of heterogeneity in proteomics analysis of the nanoparticle protein corona across core facilities," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    3. Serena Renzi & Luca Digiacomo & Daniela Pozzi & Erica Quagliarini & Elisabetta Vulpis & Maria Valeria Giuli & Angelica Mancusi & Bianca Natiello & Maria Gemma Pignataro & Gianluca Canettieri & Laura M, 2024. "Structuring lipid nanoparticles, DNA, and protein corona into stealth bionanoarchitectures for in vivo gene delivery," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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