IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-11622-x.html
   My bibliography  Save this article

Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort

Author

Listed:
  • Nicola P. Bondonno

    (Edith Cowan University
    University of Western Australia, Royal Perth Hospital)

  • Frederik Dalgaard

    (Herlev & Gentofte University Hospital)

  • Cecilie Kyrø

    (The Danish Cancer Society Research Centre)

  • Kevin Murray

    (University of Western Australia)

  • Catherine P. Bondonno

    (Edith Cowan University
    University of Western Australia, Royal Perth Hospital)

  • Joshua R. Lewis

    (Edith Cowan University
    University of Western Australia, Royal Perth Hospital)

  • Kevin D. Croft

    (Edith Cowan University)

  • Gunnar Gislason

    (Herlev & Gentofte University Hospital
    University of Southern Denmark
    The Danish Heart Foundation)

  • Augustin Scalbert

    (International Agency for Research on Cancer)

  • Aedin Cassidy

    (Queen’s University Belfast)

  • Anne Tjønneland

    (The Danish Cancer Society Research Centre)

  • Kim Overvad

    (Aarhus University
    Aalborg University Hospital)

  • Jonathan M. Hodgson

    (Edith Cowan University
    University of Western Australia, Royal Perth Hospital)

Abstract

Flavonoids, plant-derived polyphenolic compounds, have been linked with health benefits. However, evidence from observational studies is incomplete; studies on cancer mortality are scarce and moderating effects of lifestyle risk factors for early mortality are unknown. In this prospective cohort study including 56,048 participants of the Danish Diet, Cancer, and Health cohort crosslinked with Danish nationwide registries and followed for 23 years, there are 14,083 deaths. A moderate habitual intake of flavonoids is inversely associated with all-cause, cardiovascular- and cancer-related mortality. This strong association plateaus at intakes of approximately 500 mg/day. Furthermore, the inverse associations between total flavonoid intake and mortality outcomes are stronger and more linear in smokers than in non-smokers, as well as in heavy (>20 g/d) vs. low-moderate (

Suggested Citation

  • Nicola P. Bondonno & Frederik Dalgaard & Cecilie Kyrø & Kevin Murray & Catherine P. Bondonno & Joshua R. Lewis & Kevin D. Croft & Gunnar Gislason & Augustin Scalbert & Aedin Cassidy & Anne Tjønneland , 2019. "Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11622-x
    DOI: 10.1038/s41467-019-11622-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-11622-x
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-11622-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11622-x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.