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Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation

Author

Listed:
  • Jemma Victoria Walker

    (University of Plymouth)

  • Heng Zhuang

    (Peking University School and Hospital of Stomatology
    Taikang Bybo Dental Group Beijing)

  • Donald Singer

    (University of Plymouth)

  • Charlotte Sara Illsley

    (University of Plymouth)

  • Wai Ling Kok

    (University of Plymouth)

  • Kishor K. Sivaraj

    (Department of Tissue Morphogenesis and University of Münster, Faculty of Medicine)

  • Yan Gao

    (University of Plymouth
    Capital Medical University)

  • Chloe Bolton

    (University of Plymouth)

  • Yuying Liu

    (University of Plymouth
    Shenyang Stomatological Hospital)

  • Mengyuan Zhao

    (Capital Medical University)

  • Portia Rebecca Clare Grayson

    (University of Plymouth)

  • Shuang Wang

    (National University of Singapore)

  • Jana Karbanová

    (Technische Universität Dresden)

  • Tim Lee

    (Keck Graduate Institute)

  • Stefano Ardu

    (Clinique Universitaire de Médecine Dentaire, Université de Genève)

  • Qingguo Lai

    (the Second Hospital of Shandong University
    Research Center of 3D Printing in Stomatology of Shandong University)

  • Jihui Liu

    (Shenyang Stomatological Hospital)

  • Moustapha Kassem

    (Odense University Hospital & University of Southern Denmark
    University of Copenhagen)

  • Shuo Chen

    (The University of Texas Health Science Center at San Antonio)

  • Kai Yang

    (Capital Medical University)

  • Yuxing Bai

    (Capital Medical University)

  • Christopher Tredwin

    (University of Plymouth)

  • Alexander C. Zambon

    (Keck Graduate Institute)

  • Denis Corbeil

    (Technische Universität Dresden)

  • Ralf Adams

    (Department of Tissue Morphogenesis and University of Münster, Faculty of Medicine)

  • Basem M. Abdallah

    (Odense University Hospital & University of Southern Denmark
    King Faisal University)

  • Bing Hu

    (University of Plymouth)

Abstract

Stem cells (SCs) receive inductive cues from the surrounding microenvironment and cells. Limited molecular evidence has connected tissue-specific mesenchymal stem cells (MSCs) with mesenchymal transit amplifying cells (MTACs). Using mouse incisor as the model, we discover a population of MSCs neibouring to the MTACs and epithelial SCs. With Notch signaling as the key regulator, we disclose molecular proof and lineage tracing evidence showing the distinct MSCs contribute to incisor MTACs and the other mesenchymal cell lineages. MTACs can feedback and regulate the homeostasis and activation of CL-MSCs through Delta-like 1 homolog (Dlk1), which balances MSCs-MTACs number and the lineage differentiation. Dlk1’s function on SCs priming and self-renewal depends on its biological forms and its gene expression is under dynamic epigenetic control. Our findings can be validated in clinical samples and applied to accelerate tooth wound healing, providing an intriguing insight of how to direct SCs towards tissue regeneration.

Suggested Citation

  • Jemma Victoria Walker & Heng Zhuang & Donald Singer & Charlotte Sara Illsley & Wai Ling Kok & Kishor K. Sivaraj & Yan Gao & Chloe Bolton & Yuying Liu & Mengyuan Zhao & Portia Rebecca Clare Grayson & S, 2019. "Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation," Nature Communications, Nature, vol. 10(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11611-0
    DOI: 10.1038/s41467-019-11611-0
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