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Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering

Author

Listed:
  • Zhong-Kai Cui

    (Southern Medical University
    University of California Los Angeles)

  • Soyon Kim

    (University of California Los Angeles)

  • Jessalyn J. Baljon

    (University of California Los Angeles)

  • Benjamin M. Wu

    (University of California Los Angeles
    University of California Los Angeles)

  • Tara Aghaloo

    (University of California Los Angeles)

  • Min Lee

    (University of California Los Angeles
    University of California Los Angeles)

Abstract

Injectable hydrogels can fill irregular defects and promote in situ tissue regrowth and regeneration. The ability of directing stem cell differentiation in a three-dimensional microenvironment for bone regeneration remains a challenge. In this study, we successfully nanoengineer an interconnected microporous networked photocrosslinkable chitosan in situ-forming hydrogel by introducing two-dimensional nanoclay particles with intercalation chemistry. The presence of the nanosilicates increases the Young’s modulus and stalls the degradation rate of the resulting hydrogels. We demonstrate that the reinforced hydrogels promote the proliferation as well as the attachment and induced the differentiation of encapsulated mesenchymal stem cells in vitro. Furthermore, we explore the effects of nanoengineered hydrogels in vivo with the critical-sized mouse calvarial defect model. Our results confirm that chitosan-montmorillonite hydrogels are able to recruit native cells and promote calvarial healing without delivery of additional therapeutic agents or stem cells, indicating their tissue engineering potential.

Suggested Citation

  • Zhong-Kai Cui & Soyon Kim & Jessalyn J. Baljon & Benjamin M. Wu & Tara Aghaloo & Min Lee, 2019. "Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11511-3
    DOI: 10.1038/s41467-019-11511-3
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    Cited by:

    1. Xianzhu Zhang & Wei Jiang & Chang Xie & Xinyu Wu & Qian Ren & Fei Wang & Xilin Shen & Yi Hong & Hongwei Wu & Youguo Liao & Yi Zhang & Renjie Liang & Wei Sun & Yuqing Gu & Tao Zhang & Yishan Chen & Wei, 2022. "Msx1+ stem cells recruited by bioactive tissue engineering graft for bone regeneration," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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