IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-11494-1.html
   My bibliography  Save this article

A family of anti-Bacteroidales peptide toxins wide-spread in the human gut microbiota

Author

Listed:
  • Michael J. Coyne

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Nathalie Béchon

    (Brigham and Women’s Hospital, Harvard Medical School
    Genetics of Biofilms Unit
    Paris Diderot University, 75013, Cellule Pasteur)

  • Leigh M. Matano

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Valentina Laclare McEneany

    (Brigham and Women’s Hospital, Harvard Medical School)

  • Maria Chatzidaki-Livanis

    (Brigham and Women’s Hospital, Harvard Medical School
    University of Ohio)

  • Laurie E. Comstock

    (Brigham and Women’s Hospital, Harvard Medical School)

Abstract

Bacteria often produce antimicrobial toxins to compete in microbial communities. Here we identify a family of broad-spectrum peptide toxins, named bacteroidetocins, produced by Bacteroidetes species. We study this toxin family using phenotypic, mutational, bioinformatic, and human metagenomic analyses. Bacteroidetocins are related to class IIa bacteriocins of Gram-positive bacteria and kill members of the Bacteroidetes phylum, including Bacteroides, Parabacteroides, and Prevotella gut species, as well as pathogenic Prevotella species. The bacteroidetocin biosynthesis genes are found in horizontally acquired mobile elements, which likely allow dissemination within the gut microbiota and may explain their wide distribution in human populations. Bacteroidetocins may have potential applications in microbiome engineering and as therapeutics for polymicrobial diseases such as bacterial vaginosis and periodontal disease.

Suggested Citation

  • Michael J. Coyne & Nathalie Béchon & Leigh M. Matano & Valentina Laclare McEneany & Maria Chatzidaki-Livanis & Laurie E. Comstock, 2019. "A family of anti-Bacteroidales peptide toxins wide-spread in the human gut microbiota," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11494-1
    DOI: 10.1038/s41467-019-11494-1
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-11494-1
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-11494-1?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jordan C. Evans & Valentina Laclare McEneany & Michael J. Coyne & Elizabeth P. Caldwell & Madeline L. Sheahan & Salena S. Von & Emily M. Coyne & Rodney K. Tweten & Laurie E. Comstock, 2022. "A proteolytically activated antimicrobial toxin encoded on a mobile plasmid of Bacteroidales induces a protective response," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11494-1. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.