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Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation

Author

Listed:
  • Neophytos Christodoulou

    (University of Cambridge, Department of Physiology, Development and Neuroscience)

  • Antonia Weberling

    (University of Cambridge, Department of Physiology, Development and Neuroscience)

  • Douglas Strathdee

    (Cancer Research UK Beatson Institute)

  • Kurt I. Anderson

    (Francis Crick Institute)

  • Paul Timpson

    (Cancer Division
    University of NSW)

  • Magdalena Zernicka-Goetz

    (University of Cambridge, Department of Physiology, Development and Neuroscience)

Abstract

Mammalian embryos change shape dramatically upon implantation. The cellular and molecular mechanism underlying this transition are largely unknown. Here, we show that this transition is directed by cross talk between the embryonic epiblast and the first extra-embryonic tissue, the trophectoderm. Specifically, we show via visualisation of a Cdx2-GFP reporter line and pharmacologically mediated loss and gain of function experiments that the epiblast provides FGF signal that results in differential fate acquisition in the multipotent trophectoderm leading to the formation of a tissue boundary within this tissue. The trophectoderm boundary becomes essential for expansion of the tissue into a multi-layered epithelium. Folding of this multi-layered trophectoderm induces spreading of the second extra-embryonic tissue, the primitive endoderm. Together, these events remodel the pre-implantation embryo into its post-implantation cylindrical shape. Our findings uncover how communication between embryonic and extra-embryonic tissues provides positional cues to drive shape changes in mammalian development during implantation.

Suggested Citation

  • Neophytos Christodoulou & Antonia Weberling & Douglas Strathdee & Kurt I. Anderson & Paul Timpson & Magdalena Zernicka-Goetz, 2019. "Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11482-5
    DOI: 10.1038/s41467-019-11482-5
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    Cited by:

    1. King Hang Tommy Mau & Donja Karimlou & David Barneda & Vincent Brochard & Christophe Royer & Bryony Leeke & Roshni A. Souza & Mélanie Pailles & Michelle Percharde & Shankar Srinivas & Alice Jouneau & , 2022. "Dynamic enlargement and mobilization of lipid droplets in pluripotent cells coordinate morphogenesis during mouse peri-implantation development," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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