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Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome

Author

Listed:
  • Jordan T. Russell

    (Institute of Food and Agricultural Sciences University of Florida)

  • Luiz F. W. Roesch

    (Universidade Federal do Pampa)

  • Malin Ördberg

    (Linköping University)

  • Jorma Ilonen

    (Turku University Hospital)

  • Mark A. Atkinson

    (University of Florida Diabetes Institute
    University of Florida)

  • Desmond A. Schatz

    (University of Florida)

  • Eric W. Triplett

    (Institute of Food and Agricultural Sciences University of Florida)

  • Johnny Ludvigsson

    (Linköping University)

Abstract

Susceptibility to many human autoimmune diseases is under strong genetic control by class II human leukocyte antigen (HLA) allele combinations. These genes remain by far the greatest risk factors in the development of type 1 diabetes and celiac disease. Despite this, little is known about HLA influences on the composition of the human gut microbiome, a potential source of environmental influence on disease. Here, using a general population cohort from the All Babies in Southeast Sweden study, we report that genetic risk for developing type 1 diabetes autoimmunity is associated with distinct changes in the gut microbiome. Both the core microbiome and beta diversity differ with HLA risk group and genotype. In addition, protective HLA haplotypes are associated with bacterial genera Intestinibacter and Romboutsia. Thus, general population cohorts are valuable in identifying potential environmental triggers or protective factors for autoimmune diseases that may otherwise be masked by strong genetic control.

Suggested Citation

  • Jordan T. Russell & Luiz F. W. Roesch & Malin Ördberg & Jorma Ilonen & Mark A. Atkinson & Desmond A. Schatz & Eric W. Triplett & Johnny Ludvigsson, 2019. "Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11460-x
    DOI: 10.1038/s41467-019-11460-x
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    Cited by:

    1. Li Zhang & Karen R. Jonscher & Zuyuan Zhang & Yi Xiong & Ryan S. Mueller & Jacob E. Friedman & Chongle Pan, 2022. "Islet autoantibody seroconversion in type-1 diabetes is associated with metagenome-assembled genomes in infant gut microbiomes," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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