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GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits

Author

Listed:
  • Raha Pazoki

    (School of Public Health, St Mary’s campus)

  • Evangelos Evangelou

    (School of Public Health, St Mary’s campus
    University of Ioannina Medical School)

  • David Mosen-Ansorena

    (School of Public Health, St Mary’s campus)

  • Rui Climaco Pinto

    (School of Public Health, St Mary’s campus
    Dementia Research Institute at Imperial College London)

  • Ibrahim Karaman

    (School of Public Health, St Mary’s campus
    Dementia Research Institute at Imperial College London)

  • Paul Blakeley

    (School of Public Health, St Mary’s campus
    Imperial College London)

  • Dipender Gill

    (School of Public Health, St Mary’s campus
    Imperial College London)

  • Verena Zuber

    (School of Public Health, St Mary’s campus)

  • Paul Elliott

    (School of Public Health, St Mary’s campus
    Dementia Research Institute at Imperial College London
    Imperial College NIHR Biomedical Research Centre
    Health Data Research UK-London)

  • Ioanna Tzoulaki

    (School of Public Health, St Mary’s campus
    University of Ioannina Medical School
    Dementia Research Institute at Imperial College London)

  • Abbas Dehghan

    (School of Public Health, St Mary’s campus
    Dementia Research Institute at Imperial College London)

Abstract

Urinary sodium and potassium excretion are associated with blood pressure (BP) and cardiovascular disease (CVD). The exact biological link between these traits is yet to be elucidated. Here, we identify 50 loci for sodium and 13 for potassium excretion in a large-scale genome-wide association study (GWAS) on urinary sodium and potassium excretion using data from 446,237 individuals of European descent from the UK Biobank study. We extensively interrogate the results using multiple analyses such as Mendelian randomization, functional assessment, co localization, genetic risk score, and pathway analyses. We identify a shared genetic component between urinary sodium and potassium expression and cardiovascular traits. Ingenuity pathway analysis shows that urinary sodium and potassium excretion loci are over-represented in behavioural response to stimuli. Our study highlights pathways that are shared between urinary sodium and potassium excretion and cardiovascular traits.

Suggested Citation

  • Raha Pazoki & Evangelos Evangelou & David Mosen-Ansorena & Rui Climaco Pinto & Ibrahim Karaman & Paul Blakeley & Dipender Gill & Verena Zuber & Paul Elliott & Ioanna Tzoulaki & Abbas Dehghan, 2019. "GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11451-y
    DOI: 10.1038/s41467-019-11451-y
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    Cited by:

    1. Parker C. Wilson & Yoshiharu Muto & Haojia Wu & Anil Karihaloo & Sushrut S. Waikar & Benjamin D. Humphreys, 2022. "Multimodal single cell sequencing implicates chromatin accessibility and genetic background in diabetic kidney disease progression," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

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