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TeraVR empowers precise reconstruction of complete 3-D neuronal morphology in the whole brain

Author

Listed:
  • Yimin Wang

    (Southeast University
    Shanghai University
    Shanghai University)

  • Qi Li

    (Shanghai University)

  • Lijuan Liu

    (Southeast University)

  • Zhi Zhou

    (Southeast University
    Allen Institute for Brain Science)

  • Zongcai Ruan

    (Southeast University)

  • Lingsheng Kong

    (Shanghai University)

  • Yaoyao Li

    (Wenzhou Medical University)

  • Yun Wang

    (Allen Institute for Brain Science)

  • Ning Zhong

    (Beijing University of Technology
    Maebashi Institute of Technology)

  • Renjie Chai

    (Southeast University
    Southeast University
    Nantong University)

  • Xiangfeng Luo

    (Shanghai University)

  • Yike Guo

    (Imperial College London)

  • Michael Hawrylycz

    (Allen Institute for Brain Science)

  • Qingming Luo

    (Huazhong University of Science and Technology)

  • Zhongze Gu

    (Southeast University)

  • Wei Xie

    (Southeast University)

  • Hongkui Zeng

    (Allen Institute for Brain Science)

  • Hanchuan Peng

    (Southeast University
    Allen Institute for Brain Science)

Abstract

Neuron morphology is recognized as a key determinant of cell type, yet the quantitative profiling of a mammalian neuron’s complete three-dimensional (3-D) morphology remains arduous when the neuron has complex arborization and long projection. Whole-brain reconstruction of neuron morphology is even more challenging as it involves processing tens of teravoxels of imaging data. Validating such reconstructions is extremely laborious. We develop TeraVR, an open-source virtual reality annotation system, to address these challenges. TeraVR integrates immersive and collaborative 3-D visualization, interaction, and hierarchical streaming of teravoxel-scale images. Using TeraVR, we have produced precise 3-D full morphology of long-projecting neurons in whole mouse brains and developed a collaborative workflow for highly accurate neuronal reconstruction.

Suggested Citation

  • Yimin Wang & Qi Li & Lijuan Liu & Zhi Zhou & Zongcai Ruan & Lingsheng Kong & Yaoyao Li & Yun Wang & Ning Zhong & Renjie Chai & Xiangfeng Luo & Yike Guo & Michael Hawrylycz & Qingming Luo & Zhongze Gu , 2019. "TeraVR empowers precise reconstruction of complete 3-D neuronal morphology in the whole brain," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11443-y
    DOI: 10.1038/s41467-019-11443-y
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    Cited by:

    1. Yufeng Liu & Shengdian Jiang & Yingxin Li & Sujun Zhao & Zhixi Yun & Zuo-Han Zhao & Lingli Zhang & Gaoyu Wang & Xin Chen & Linus Manubens-Gil & Yuning Hang & Qiaobo Gong & Yuanyuan Li & Penghao Qian &, 2024. "Neuronal diversity and stereotypy at multiple scales through whole brain morphometry," Nature Communications, Nature, vol. 15(1), pages 1-23, December.

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