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Diurnal rhythms in gene expression in the prefrontal cortex in schizophrenia

Author

Listed:
  • Marianne L. Seney

    (University of Pittsburgh)

  • Kelly Cahill

    (University of Pittsburgh)

  • John F. Enwright

    (University of Pittsburgh)

  • Ryan W. Logan

    (University of Pittsburgh)

  • Zhiguang Huo

    (University of Florida)

  • Wei Zong

    (University of Pittsburgh)

  • George Tseng

    (University of Pittsburgh)

  • Colleen A. McClung

    (University of Pittsburgh)

Abstract

Schizophrenia is associated with disrupted cognitive control and sleep-wake cycles. Here we identify diurnal rhythms in gene expression in the human dorsolateral prefrontal cortex (dlPFC), in schizophrenia and control subjects. We find significant diurnal (24 h) rhythms in control subjects, however, most of these transcripts are not rhythmic in subjects with schizophrenia. Instead, subjects with schizophrenia have a different set of rhythmic transcripts. The top pathways identified in transcripts rhythmic only in subjects with schizophrenia are associated with mitochondrial function. Importantly, these rhythms drive differential expression patterns of these and several other genes that have long been implicated in schizophrenia (including BDNF and GABAergic-related transcripts). Indeed, differential expression of these transcripts is only seen in subjects that died during the night, with no change in subjects that died during the day. These data provide insights into a potential mechanism that underlies changes in gene expression in the dlPFC with schizophrenia.

Suggested Citation

  • Marianne L. Seney & Kelly Cahill & John F. Enwright & Ryan W. Logan & Zhiguang Huo & Wei Zong & George Tseng & Colleen A. McClung, 2019. "Diurnal rhythms in gene expression in the prefrontal cortex in schizophrenia," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
  • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11335-1
    DOI: 10.1038/s41467-019-11335-1
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    Cited by:

    1. Jackson N. Cagle & Tiberio de Araujo & Kara A. Johnson & John Yu & Lauren Fanty & Filipe P. Sarmento & Simon Little & Michael S. Okun & Joshua K. Wong & Coralie de Hemptinne, 2024. "Chronic intracranial recordings in the globus pallidus reveal circadian rhythms in Parkinson’s disease," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    2. Jingkuan Wei & Shaoxing Dai & Yaping Yan & Shulin Li & Pengpeng Yang & Ran Zhu & Tianzhuang Huang & Xi Li & Yanchao Duan & Zhengbo Wang & Weizhi Ji & Wei Si, 2023. "Spatiotemporal proteomic atlas of multiple brain regions across early fetal to neonatal stages in cynomolgus monkey," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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