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A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration

Author

Listed:
  • James T. Handa

    (Johns Hopkins University)

  • Cathy Bowes Rickman

    (Duke University Medical Center)

  • Andrew D. Dick

    (University of Bristol
    Moorfields Eye Hospital and UCL-Institute of Ophthalmology)

  • Michael B. Gorin

    (UCLA
    UCLA)

  • Joan W. Miller

    (Harvard Medical School)

  • Cynthia A. Toth

    (Duke University Medical Center)

  • Marius Ueffing

    (University of Tübingen)

  • Marco Zarbin

    (Rutgers University)

  • Lindsay A. Farrer

    (Boston University Schools of Medicine and Public Health)

Abstract

Age-related macular degeneration (AMD) is the most common cause of blindness among the elderly in the developed world. While treatment is effective for the neovascular or “wet” form of AMD, no therapy is successful for the non-neovascular or “dry” form. Here we discuss the current knowledge on dry AMD pathobiology and propose future research directions that would expedite the development of new treatments. In our view, these should emphasize system biology approaches that integrate omic, pharmacological, and clinical data into mathematical models that can predict disease onset and progression, identify biomarkers, establish disease causing mechanisms, and monitor response to therapy.

Suggested Citation

  • James T. Handa & Cathy Bowes Rickman & Andrew D. Dick & Michael B. Gorin & Joan W. Miller & Cynthia A. Toth & Marius Ueffing & Marco Zarbin & Lindsay A. Farrer, 2019. "A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11262-1
    DOI: 10.1038/s41467-019-11262-1
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    Cited by:

    1. Amil M. Shah & Peder L. Myhre & Victoria Arthur & Pranav Dorbala & Humaira Rasheed & Leo F. Buckley & Brian Claggett & Guning Liu & Jianzhong Ma & Ngoc Quynh Nguyen & Kunihiro Matsushita & Chiadi Ndum, 2024. "Large scale plasma proteomics identifies novel proteins and protein networks associated with heart failure development," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Sayan Ghosh & Ruchi Sharma & Sridhar Bammidi & Victoria Koontz & Mihir Nemani & Meysam Yazdankhah & Katarzyna M. Kedziora & Donna Beer Stolz & Callen T. Wallace & Cheng Yu-Wei & Jonathan Franks & Devi, 2024. "The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in non-neovascular AMD," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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