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EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming

Author

Listed:
  • Nicolas Istaces

    (Institute for Medical Immunology (IMI))

  • Marion Splittgerber

    (Institute for Medical Immunology (IMI))

  • Viviana Lima Silva

    (Institute for Medical Immunology (IMI))

  • Muriel Nguyen

    (Institute for Medical Immunology (IMI))

  • Séverine Thomas

    (Institute for Medical Immunology (IMI))

  • Aurore Le

    (Institute for Medical Immunology (IMI))

  • Younes Achouri

    (Institut de Duve)

  • Emilie Calonne

    (Laboratory of Cancer Epigenetics)

  • Matthieu Defrance

    (Interuniversity Institute of Bioinformatics in Brussels (IB2))

  • François Fuks

    (Laboratory of Cancer Epigenetics)

  • Stanislas Goriely

    (Institute for Medical Immunology (IMI))

  • Abdulkader Azouz

    (Institute for Medical Immunology (IMI))

Abstract

Memory CD8+ T cells have the ability to provide lifelong immunity against pathogens. Although memory features generally arise after challenge with a foreign antigen, naïve CD8 single positive (SP) thymocytes may acquire phenotypic and functional characteristics of memory cells in response to cytokines such as interleukin-4. This process is associated with the induction of the T-box transcription factor Eomesodermin (EOMES). However, the underlying molecular mechanisms remain ill-defined. Using epigenomic profiling, we show that these innate memory CD8SP cells acquire only a portion of the active enhancer repertoire of conventional memory cells. This reprograming is secondary to EOMES recruitment, mostly to RUNX3-bound enhancers. Furthermore, EOMES is found within chromatin-associated complexes containing BRG1 and promotes the recruitment of this chromatin remodelling factor. Also, the in vivo acquisition of EOMES-dependent program is BRG1-dependent. In conclusion, our results support a strong epigenetic basis for the EOMES-driven establishment of CD8+ T cell innate memory program.

Suggested Citation

  • Nicolas Istaces & Marion Splittgerber & Viviana Lima Silva & Muriel Nguyen & Séverine Thomas & Aurore Le & Younes Achouri & Emilie Calonne & Matthieu Defrance & François Fuks & Stanislas Goriely & Abd, 2019. "EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming," Nature Communications, Nature, vol. 10(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11233-6
    DOI: 10.1038/s41467-019-11233-6
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    Cited by:

    1. Hussein A. Abbas & Dapeng Hao & Katarzyna Tomczak & Praveen Barrodia & Jin Seon Im & Patrick K. Reville & Zoe Alaniz & Wei Wang & Ruiping Wang & Feng Wang & Gheath Al-Atrash & Koichi Takahashi & Jing , 2021. "Single cell T cell landscape and T cell receptor repertoire profiling of AML in context of PD-1 blockade therapy," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

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