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Two types of functionally distinct Ca2+ stores in hippocampal neurons

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  • Hsing-Jung Chen-Engerer

    (Technical University of Munich
    Munich Cluster for Systems Neurology (SyNergy) and Center for Integrated Protein Sciences (CIPSM))

  • Jana Hartmann

    (Technical University of Munich
    Munich Cluster for Systems Neurology (SyNergy) and Center for Integrated Protein Sciences (CIPSM))

  • Rosa Maria Karl

    (Technical University of Munich
    Munich Cluster for Systems Neurology (SyNergy) and Center for Integrated Protein Sciences (CIPSM))

  • Jun Yang

    (New York University)

  • Stefan Feske

    (New York University)

  • Arthur Konnerth

    (Technical University of Munich
    Munich Cluster for Systems Neurology (SyNergy) and Center for Integrated Protein Sciences (CIPSM))

Abstract

It is widely assumed that inositol trisphosphate (IP3) and ryanodine (Ry) receptors share the same Ca2+ pool in central mammalian neurons. We now demonstrate that in hippocampal CA1 pyramidal neurons IP3- and Ry-receptors are associated with two functionally distinct intracellular Ca2+ stores, respectively. While the IP3-sensitive Ca2+ store refilling requires Orai2 channels, Ry-sensitive Ca2+ store refilling involves voltage-gated Ca2+ channels (VGCCs). Our findings have direct implications for the understanding of function and plasticity in these central mammalian neurons.

Suggested Citation

  • Hsing-Jung Chen-Engerer & Jana Hartmann & Rosa Maria Karl & Jun Yang & Stefan Feske & Arthur Konnerth, 2019. "Two types of functionally distinct Ca2+ stores in hippocampal neurons," Nature Communications, Nature, vol. 10(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11207-8
    DOI: 10.1038/s41467-019-11207-8
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