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Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936

Author

Listed:
  • Robert F. Hillary

    (University of Edinburgh)

  • Daniel L. McCartney

    (University of Edinburgh)

  • Sarah E. Harris

    (University of Edinburgh
    University of Edinburgh)

  • Anna J. Stevenson

    (University of Edinburgh)

  • Anne Seeboth

    (University of Edinburgh)

  • Qian Zhang

    (University of Queensland)

  • David C. Liewald

    (University of Edinburgh)

  • Kathryn L. Evans

    (University of Edinburgh
    University of Edinburgh)

  • Craig W. Ritchie

    (University of Edinburgh)

  • Elliot M. Tucker-Drob

    (The University of Texas at Austin
    The University of Texas at Austin)

  • Naomi R. Wray

    (University of Queensland)

  • Allan F. McRae

    (University of Queensland)

  • Peter M. Visscher

    (University of Queensland)

  • Ian J. Deary

    (University of Edinburgh
    University of Edinburgh)

  • Riccardo E. Marioni

    (University of Edinburgh
    University of Edinburgh)

Abstract

Although plasma proteins may serve as markers of neurological disease risk, the molecular mechanisms responsible for inter-individual variation in plasma protein levels are poorly understood. Therefore, we conduct genome- and epigenome-wide association studies on the levels of 92 neurological proteins to identify genetic and epigenetic loci associated with their plasma concentrations (n = 750 healthy older adults). We identify 41 independent genome-wide significant (P

Suggested Citation

  • Robert F. Hillary & Daniel L. McCartney & Sarah E. Harris & Anna J. Stevenson & Anne Seeboth & Qian Zhang & David C. Liewald & Kathryn L. Evans & Craig W. Ritchie & Elliot M. Tucker-Drob & Naomi R. Wr, 2019. "Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11177-x
    DOI: 10.1038/s41467-019-11177-x
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