IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-11162-4.html
   My bibliography  Save this article

circTP63 functions as a ceRNA to promote lung squamous cell carcinoma progression by upregulating FOXM1

Author

Listed:
  • Zhuoan Cheng

    (Shanghai Jiao Tong University School of Biomedical Engineering)

  • Chengtao Yu

    (Shanghai Jiao Tong University School of Biomedical Engineering)

  • Shaohua Cui

    (Shanghai Jiao Tong University)

  • Hui Wang

    (Shanghai Jiao Tong University School of Medicine)

  • Haojie Jin

    (Shanghai Jiao Tong University School of Medicine)

  • Cun Wang

    (Shanghai Jiao Tong University School of Medicine)

  • Botai Li

    (Shanghai Jiao Tong University School of Biomedical Engineering)

  • Meilin Qin

    (Shanghai Jiao Tong University School of Medicine)

  • Chen Yang

    (Shanghai Medical College of Fudan University)

  • Jia He

    (Shanghai Jiao Tong University School of Medicine)

  • Qiaozhu Zuo

    (Shanghai Jiao Tong University School of Medicine)

  • Siying Wang

    (Shanghai Jiao Tong University School of Medicine)

  • Jun Liu

    (Shanghai Jiao Tong University)

  • Weidong Ye

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

  • Yuanyuan Lv

    (Shanghai Jiao Tong University School of Medicine)

  • Fangyu Zhao

    (Shanghai Jiao Tong University School of Medicine)

  • Ming Yao

    (Shanghai Jiao Tong University School of Medicine)

  • Liyan Jiang

    (Shanghai Jiao Tong University)

  • Wenxin Qin

    (Shanghai Jiao Tong University School of Biomedical Engineering
    Shanghai Jiao Tong University School of Medicine)

Abstract

Circular RNAs (circRNAs) are identified as vital regulators in a variety of cancers. However, the role of circRNA in lung squamous cell carcinoma (LUSC) remains largely unknown. Herein, we explore the expression profiles of circRNA and mRNA in 5 paired samples of LUSC. By analyzing the co-expression network of differentially expressed circRNAs and dysregulated mRNAs, we identify that a cell cycle-related circRNA, circTP63, is upregulated in LUSC tissues and its upregulation is correlated with larger tumor size and higher TNM stage in LUSC patients. Elevated circTP63 promotes cell proliferation both in vitro and in vivo. Mechanistically, circTP63 shares miRNA response elements with FOXM1. circTP63 competitively binds to miR-873-3p and prevents miR-873-3p to decrease the level of FOXM1, which upregulates CENPA and CENPB, and finally facilitates cell cycle progression.

Suggested Citation

  • Zhuoan Cheng & Chengtao Yu & Shaohua Cui & Hui Wang & Haojie Jin & Cun Wang & Botai Li & Meilin Qin & Chen Yang & Jia He & Qiaozhu Zuo & Siying Wang & Jun Liu & Weidong Ye & Yuanyuan Lv & Fangyu Zhao , 2019. "circTP63 functions as a ceRNA to promote lung squamous cell carcinoma progression by upregulating FOXM1," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11162-4
    DOI: 10.1038/s41467-019-11162-4
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-11162-4
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-11162-4?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11162-4. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.