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Inflammation triggers immediate rather than progressive changes in monocyte differentiation in the small intestine

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  • Girmay Desalegn

    (RWTH Aachen University
    Hannover Medical School)

  • Oliver Pabst

    (RWTH Aachen University)

Abstract

Bone marrow-derived circulating monocytes contribute to the replenishment and maintenance of the intestinal macrophage population. Intestinal monocytes undergo context-dependent phenotypic and functional adaptations to either maintain local immune balance or support intestinal inflammation. Here we use monocyte adoptive transfer to dissect the dynamics of monocyte-to-macrophage differentiation in normal and inflamed small intestine. We find that during homeostasis CCR2 and β7-integrin mediate constitutive homing of monocytes to the gut. By contrast, intestinal inflammation increases monocyte recruitment via CCR2, but not β7-integrin. In the non-inflamed intestine, monocytes gradually differentiate to express genes typically associated with tolerogenic macrophage functions. Conversely, immediately upon entry into the inflamed intestine, monocytes adapt a different expression pattern in a partly Trem-1-dependent manner. Our observations suggest that inflammation fundamentally changes the kinetics and modalities of monocyte differentiation in tissues.

Suggested Citation

  • Girmay Desalegn & Oliver Pabst, 2019. "Inflammation triggers immediate rather than progressive changes in monocyte differentiation in the small intestine," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11148-2
    DOI: 10.1038/s41467-019-11148-2
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