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The nasal methylome as a biomarker of asthma and airway inflammation in children

Author

Listed:
  • Andres Cardenas

    (University of California, Berkeley
    Harvard Medical School and Harvard Pilgrim Health Care Institute)

  • Joanne E. Sordillo

    (Harvard Medical School and Harvard Pilgrim Health Care Institute)

  • Sheryl L. Rifas-Shiman

    (Harvard Medical School and Harvard Pilgrim Health Care Institute)

  • Wonil Chung

    (Harvard T.H. Chan School of Public Health)

  • Liming Liang

    (Harvard T.H. Chan School of Public Health)

  • Brent A. Coull

    (Harvard T.H. Chan School of Public Health)

  • Marie-France Hivert

    (Harvard Medical School and Harvard Pilgrim Health Care Institute
    Massachusetts General Hospital)

  • Peggy S. Lai

    (Pulmonary/Critical Care)

  • Erick Forno

    (University of Pittsburgh School of Medicine)

  • Juan C. Celedón

    (University of Pittsburgh School of Medicine)

  • Augusto A. Litonjua

    (University of Rochester Medical Center)

  • Kasey J. Brennan

    (Mailman School of Public Health, Columbia University)

  • Dawn L. DeMeo

    (Harvard Medical School)

  • Andrea A. Baccarelli

    (Mailman School of Public Health, Columbia University)

  • Emily Oken

    (Harvard Medical School and Harvard Pilgrim Health Care Institute)

  • Diane R. Gold

    (Harvard Medical School
    Harvard T. H. Chan School of Public Health)

Abstract

The nasal cellular epigenome may serve as biomarker of airway disease and environmental response. Here we collect nasal swabs from the anterior nares of 547 children (mean-age 12.9 y), and measure DNA methylation (DNAm) with the Infinium MethylationEPIC BeadChip. We perform nasal Epigenome-Wide Association analyses (EWAS) of current asthma, allergen sensitization, allergic rhinitis, fractional exhaled nitric oxide (FeNO) and lung function. We find multiple differentially methylated CpGs (FDR

Suggested Citation

  • Andres Cardenas & Joanne E. Sordillo & Sheryl L. Rifas-Shiman & Wonil Chung & Liming Liang & Brent A. Coull & Marie-France Hivert & Peggy S. Lai & Erick Forno & Juan C. Celedón & Augusto A. Litonjua &, 2019. "The nasal methylome as a biomarker of asthma and airway inflammation in children," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11058-3
    DOI: 10.1038/s41467-019-11058-3
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    Cited by:

    1. Merlijn Breugel & Cancan Qi & Zhongli Xu & Casper-Emil T. Pedersen & Ilya Petoukhov & Judith M. Vonk & Ulrike Gehring & Marijn Berg & Marnix Bügel & Orestes A. Carpaij & Erick Forno & Andréanne Morin , 2022. "Nasal DNA methylation at three CpG sites predicts childhood allergic disease," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Zhaozhong Zhu & Yijun Li & Robert J. Freishtat & Juan C. Celedón & Janice A. Espinola & Brennan Harmon & Andrea Hahn & Carlos A. Camargo & Liming Liang & Kohei Hasegawa, 2023. "Epigenome-wide association analysis of infant bronchiolitis severity: a multicenter prospective cohort study," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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