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Landscape of transcriptomic interactions between breast cancer and its microenvironment

Author

Listed:
  • Natalie S. Fox

    (Ontario Institute for Cancer Research
    University of Toronto)

  • Syed Haider

    (Ontario Institute for Cancer Research
    University of Oxford
    The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research)

  • Adrian L. Harris

    (University of Oxford)

  • Paul C. Boutros

    (Ontario Institute for Cancer Research
    University of Toronto
    University of Toronto
    University of California)

Abstract

Solid tumours comprise mixtures of tumour cells (TCs) and tumour-adjacent cells (TACs), and the intricate interconnections between these diverse populations shape the tumour’s microenvironment. Despite this complexity, clinical genomic profiling is typically performed from bulk samples, without distinguishing TCs from TACs. To better understand TC–TAC interactions, we computationally distinguish their transcriptomes in 1780 primary breast tumours. We show that TC and TAC mRNA abundances are divergently associated with clinical phenotypes, including tumour subtypes and patient survival. These differences reflect distinct responses of TCs and TACs to specific somatic driver mutations, particularly TP53. These data further elucidate how the molecular interplay between breast tumours and their microenvironment drives aggressive tumour phenotypes.

Suggested Citation

  • Natalie S. Fox & Syed Haider & Adrian L. Harris & Paul C. Boutros, 2019. "Landscape of transcriptomic interactions between breast cancer and its microenvironment," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10929-z
    DOI: 10.1038/s41467-019-10929-z
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    Cited by:

    1. Kang Wang & Ioannis Zerdes & Henrik J. Johansson & Dhifaf Sarhan & Yizhe Sun & Dimitris C. Kanellis & Emmanouil G. Sifakis & Artur Mezheyeuski & Xingrong Liu & Niklas Loman & Ingrid Hedenfalk & Jonas , 2024. "Longitudinal molecular profiling elucidates immunometabolism dynamics in breast cancer," Nature Communications, Nature, vol. 15(1), pages 1-24, December.

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