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Country-wide medical records infer increased allergy risk of gastric acid inhibition

Author

Listed:
  • Galateja Jordakieva

    (Medical University of Vienna
    Medical University of Vienna
    University of Veterinary Medicine Vienna, Medical University Vienna, University of Vienna)

  • Michael Kundi

    (Medical University of Vienna)

  • Eva Untersmayr

    (Medical University of Vienna)

  • Isabella Pali-Schöll

    (Medical University of Vienna
    University of Veterinary Medicine Vienna, Medical University Vienna, University of Vienna)

  • Berthold Reichardt

    (Sickness Fund Burgenland)

  • Erika Jensen-Jarolim

    (Medical University of Vienna
    University of Veterinary Medicine Vienna, Medical University Vienna, University of Vienna)

Abstract

Gastric acid suppression promotes allergy in mechanistic animal experiments and observational human studies, but whether gastric acid inhibitors increase allergy incidence at a population level remains uncharacterized. Here we aim to assess the use of anti-allergic medication following prescription of gastric acid inhibitors. We analyze data from health insurance records covering 97% of Austrian population between 2009 and 2013 on prescriptions of gastric acid inhibitors, anti-allergic drugs, or other commonly prescribed (lipid-modifying and antihypertensive) drugs as controls. Here we show that rate ratios for anti-allergic following gastric acid-inhibiting drug prescriptions are 1.96 (95%CI:1.95–1.97) and 3.07 (95%-CI:2.89–3.27) in an overall and regional Austrian dataset. These findings are more prominent in women and occur for all assessed gastric acid-inhibiting substances. Rate ratios increase from 1.47 (95%CI:1.45–1.49) in subjects 60 year olds. We report an epidemiologic relationship between gastric acid-suppression and development of allergic symptoms.

Suggested Citation

  • Galateja Jordakieva & Michael Kundi & Eva Untersmayr & Isabella Pali-Schöll & Berthold Reichardt & Erika Jensen-Jarolim, 2019. "Country-wide medical records infer increased allergy risk of gastric acid inhibition," Nature Communications, Nature, vol. 10(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10914-6
    DOI: 10.1038/s41467-019-10914-6
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