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Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART

Author

Listed:
  • Nadine Bachmann

    (University Hospital Zurich
    University of Zurich)

  • Chantal Siebenthal

    (University Hospital Zurich
    University of Zurich)

  • Valentina Vongrad

    (University Hospital Zurich
    University of Zurich)

  • Teja Turk

    (University Hospital Zurich
    University of Zurich)

  • Kathrin Neumann

    (University Hospital Zurich
    University of Zurich)

  • Niko Beerenwinkel

    (Department of Biosystems Science and Engineering, ETH Zurich
    SIB Swiss Institute of Bioinformatics)

  • Jasmina Bogojeska

    (IBM Research—Zurich)

  • Jaques Fellay

    (School of Life Sciences, EPFL
    Precision Medicine Unit, Lausanne University Hospital)

  • Volker Roth

    (University of Basel)

  • Yik Lim Kok

    (University Hospital Zurich
    University of Zurich)

  • Christian W. Thorball

    (School of Life Sciences, EPFL)

  • Alessandro Borghesi

    (School of Life Sciences, EPFL
    Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo)

  • Sonali Parbhoo

    (University of Basel)

  • Mario Wieser

    (University of Basel)

  • Jürg Böni

    (University of Zurich)

  • Matthieu Perreau

    (University of Lausanne)

  • Thomas Klimkait

    (University of Basel)

  • Sabine Yerly

    (University Hospital Geneva, University of Geneva)

  • Manuel Battegay

    (University Hospital Basel)

  • Andri Rauch

    (University Hospital Bern)

  • Matthias Hoffmann

    (Division of Infectious Diseases, Cantonal Hospital of St. Gallen)

  • Enos Bernasconi

    (Infectious Diseases Service, Regional Hospital)

  • Matthias Cavassini

    (Centre Hospitalier Universitaire Vaudois, University of Lausanne)

  • Roger D. Kouyos

    (University Hospital Zurich
    University of Zurich)

  • Huldrych F. Günthard

    (University Hospital Zurich
    University of Zurich)

  • Karin J. Metzner

    (University Hospital Zurich
    University of Zurich)

Abstract

The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for a median of 5.4 years. At the population level, the reservoir decreases with diminishing differences over time, but increases in 26.6% of individuals. Viral blips and low-level viremia are significantly associated with slower reservoir decay. Initiation of ART within the first year of infection, pretreatment viral load, and ethnicity affect reservoir size, but less so long-term dynamics. Viral blips and low-level viremia are thus relevant for reservoir and cure studies.

Suggested Citation

  • Nadine Bachmann & Chantal Siebenthal & Valentina Vongrad & Teja Turk & Kathrin Neumann & Niko Beerenwinkel & Jasmina Bogojeska & Jaques Fellay & Volker Roth & Yik Lim Kok & Christian W. Thorball & Ale, 2019. "Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10884-9
    DOI: 10.1038/s41467-019-10884-9
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    Cited by:

    1. Xiaolei Wang & Eunice Vincent & Summer Siddiqui & Katherine Turnbull & Hong Lu & Robert Blair & Xueling Wu & Meagan Watkins & Widade Ziani & Jiasheng Shao & Lara A. Doyle-Meyers & Kasi E. Russell-Lodr, 2022. "Early treatment regimens achieve sustained virologic remission in infant macaques infected with SIV at birth," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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