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Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3

Author

Listed:
  • Dongwon Kim

    (Johns Hopkins University School of Medicine)

  • Ruosi Chen

    (Johns Hopkins University School of Medicine
    Nanfang Hospital of Southern Medical University)

  • Mary Sheu

    (Johns Hopkins University School of Medicine)

  • Noori Kim

    (Johns Hopkins University School of Medicine)

  • Sooah Kim

    (Johns Hopkins University School of Medicine)

  • Nasif Islam

    (Johns Hopkins University School of Medicine)

  • Eric M. Wier

    (Johns Hopkins University School of Medicine)

  • Gaofeng Wang

    (Johns Hopkins University School of Medicine
    Nanfang Hospital of Southern Medical University)

  • Ang Li

    (Johns Hopkins University School of Medicine)

  • Angela Park

    (Johns Hopkins University School of Medicine)

  • Wooyang Son

    (Johns Hopkins University School of Medicine)

  • Benjamin Evans

    (Johns Hopkins University School of Medicine)

  • Victoria Yu

    (Johns Hopkins University School of Medicine)

  • Vicky P. Prizmic

    (Johns Hopkins University School of Medicine)

  • Eugene Oh

    (Johns Hopkins University School of Medicine)

  • Zixiao Wang

    (Johns Hopkins University School of Medicine)

  • Jianshi Yu

    (University of Maryland)

  • Weiliang Huang

    (University of Maryland)

  • Nathan K. Archer

    (Johns Hopkins University School of Medicine)

  • Zhiqi Hu

    (Nanfang Hospital of Southern Medical University)

  • Nashay Clemetson

    (Johns Hopkins University School of Medicine)

  • Amanda M. Nelson

    (The Pennsylvania State University)

  • Anna Chien

    (Johns Hopkins University School of Medicine)

  • Ginette A. Okoye

    (Johns Hopkins University School of Medicine)

  • Lloyd S. Miller

    (Johns Hopkins University School of Medicine)

  • Gabriel Ghiaur

    (Johns Hopkins University School of Medicine)

  • Sewon Kang

    (Johns Hopkins University School of Medicine)

  • Jace W. Jones

    (University of Maryland)

  • Maureen A. Kane

    (University of Maryland)

  • Luis A. Garza

    (Johns Hopkins University School of Medicine)

Abstract

How developmental programs reactivate in regeneration is a fundamental question in biology. We addressed this question through the study of Wound Induced Hair follicle Neogenesis (WIHN), an adult organogenesis model where stem cells regenerate de novo hair follicles following deep wounding. The exact mechanism is uncertain. Here we show that self-noncoding dsRNA activates the anti-viral receptor toll like receptor 3 (TLR3) to induce intrinsic retinoic acid (RA) synthesis in a pattern that predicts new hair follicle formation after wounding in mice. Additionally, in humans, rejuvenation lasers induce gene expression signatures for dsRNA and RA, with measurable increases in intrinsic RA synthesis. These results demonstrate a potent stimulus for RA synthesis by non-coding dsRNA, relevant to their broad functions in development and immunity.

Suggested Citation

  • Dongwon Kim & Ruosi Chen & Mary Sheu & Noori Kim & Sooah Kim & Nasif Islam & Eric M. Wier & Gaofeng Wang & Ang Li & Angela Park & Wooyang Son & Benjamin Evans & Victoria Yu & Vicky P. Prizmic & Eugene, 2019. "Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10811-y
    DOI: 10.1038/s41467-019-10811-y
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    Cited by:

    1. Yang Yang & Chenyu Chu & Li Liu & Chenbing Wang & Chen Hu & Shengan Rung & Yi Man & Yili Qu, 2023. "Tracing immune cells around biomaterials with spatial anchors during large-scale wound regeneration," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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