IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-10787-9.html
   My bibliography  Save this article

Zero-field nuclear magnetic resonance of chemically exchanging systems

Author

Listed:
  • Danila A. Barskiy

    (University of California—Berkeley
    Lawrence Berkeley National Laboratory)

  • Michael C. D. Tayler

    (University of Cambridge
    The Institute of Photonic Sciences)

  • Irene Marco-Rius

    (University of California—San Francisco
    The Barcelona Institute of Science and Technology)

  • John Kurhanewicz

    (University of California—San Francisco)

  • Daniel B. Vigneron

    (University of California—San Francisco)

  • Sevil Cikrikci

    (University of California—Berkeley
    Middle East Technical University)

  • Ayca Aydogdu

    (University of California—Berkeley
    Middle East Technical University)

  • Moritz Reh

    (University of California—Berkeley)

  • Andrey N. Pravdivtsev

    (Kiel University)

  • Jan-Bernd Hövener

    (Kiel University)

  • John W. Blanchard

    (Johannes Gutenberg-Universität)

  • Teng Wu

    (Johannes Gutenberg-Universität)

  • Dmitry Budker

    (University of California—Berkeley
    Johannes Gutenberg-Universität)

  • Alexander Pines

    (University of California—Berkeley
    Lawrence Berkeley National Laboratory)

Abstract

Zero- to ultralow-field (ZULF) nuclear magnetic resonance (NMR) is an emerging tool for precision chemical analysis. In this work, we study dynamic processes and investigate the influence of chemical exchange on ZULF NMR J-spectra. We develop a computational approach that allows quantitative calculation of J-spectra in the presence of chemical exchange and apply it to study aqueous solutions of [15N]ammonium (15N $${\mathrm{H}}_4^ +$$ H 4 + ) as a model system. We show that pH-dependent chemical exchange substantially affects the J-spectra and, in some cases, can lead to degradation and complete disappearance of the spectral features. To demonstrate potential applications of ZULF NMR for chemistry and biomedicine, we show a ZULF NMR spectrum of [2-13C]pyruvic acid hyperpolarized via dissolution dynamic nuclear polarization (dDNP). We foresee applications of affordable and scalable ZULF NMR coupled with hyperpolarization to study chemical exchange phenomena in vivo and in situations where high-field NMR detection is not possible to implement.

Suggested Citation

  • Danila A. Barskiy & Michael C. D. Tayler & Irene Marco-Rius & John Kurhanewicz & Daniel B. Vigneron & Sevil Cikrikci & Ayca Aydogdu & Moritz Reh & Andrey N. Pravdivtsev & Jan-Bernd Hövener & John W. B, 2019. "Zero-field nuclear magnetic resonance of chemically exchanging systems," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10787-9
    DOI: 10.1038/s41467-019-10787-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-10787-9
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-10787-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Román Picazo-Frutos & Kirill F. Sheberstov & John W. Blanchard & Erik Dyke & Moritz Reh & Tobias Sjoelander & Alexander Pines & Dmitry Budker & Danila A. Barskiy, 2024. "Zero-field J-spectroscopy of quadrupolar nuclei," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10787-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.