IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-10784-y.html
   My bibliography  Save this article

NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPARγ

Author

Listed:
  • Peipei Luan

    (Tongji University
    School of Medicine)

  • Weixia Jian

    (School of Medicine)

  • Xu Xu

    (Tongji University)

  • Wenxin Kou

    (Tongji University)

  • Qing Yu

    (Tongji University)

  • Handan Hu

    (East China Normal University)

  • Dali Li

    (East China Normal University)

  • Wei Wang

    (Columbia University Medical Center)

  • Mark W. Feinberg

    (Harvard Medical School)

  • Jianhui Zhuang

    (Tongji University)

  • Yawei Xu

    (Tongji University)

  • Wenhui Peng

    (Tongji University)

Abstract

NLR Family CARD Domain Containing 5 (NLRC5), an important immune regulator in innate immunity, is involved in regulating inflammation and antigen presentation. However, the role of NLRC5 in vascular remodeling remains unknown. Here we report the role of NLRC5 on vascular remodeling and provide a better understanding of its underlying mechanism. Nlrc5 knockout (Nlrc5−/−) mice exhibit more severe intimal hyperplasia compared with wild-type mice after carotid ligation. Ex vivo data shows that NLRC5 deficiency leads to increased proliferation and migration of human aortic smooth muscle cells (HASMCs). NLRC5 binds to PPARγ and inhibits HASMC dedifferentiation. NACHT domain of NLRC5 is essential for the interaction with PPARγ and stimulation of PPARγ activity. Pioglitazone significantly rescues excessive intimal hyperplasia in Nlrc5−/− mice and attenuates the increased proliferation and dedifferentiation in NLRC5-deficient HASMCs. Our study demonstrates that NLRC5 regulates vascular remodeling by directly inhibiting SMC dysfunction via its interaction with PPARγ.

Suggested Citation

  • Peipei Luan & Weixia Jian & Xu Xu & Wenxin Kou & Qing Yu & Handan Hu & Dali Li & Wei Wang & Mark W. Feinberg & Jianhui Zhuang & Yawei Xu & Wenhui Peng, 2019. "NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPARγ," Nature Communications, Nature, vol. 10(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10784-y
    DOI: 10.1038/s41467-019-10784-y
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-10784-y
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-10784-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10784-y. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.