IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-10765-1.html
   My bibliography  Save this article

Immature excitatory neurons develop during adolescence in the human amygdala

Author

Listed:
  • Shawn F. Sorrells

    (University of California, San Francisco
    University of California, San Francisco)

  • Mercedes F. Paredes

    (University of California, San Francisco)

  • Dmitry Velmeshev

    (University of California, San Francisco)

  • Vicente Herranz-Pérez

    (CIBERNED
    Universitat Jaume I)

  • Kadellyn Sandoval

    (University of California, San Francisco)

  • Simone Mayer

    (University of California, San Francisco)

  • Edward F. Chang

    (University of California, San Francisco)

  • Ricardo Insausti

    (University of Castilla-La Mancha)

  • Arnold R. Kriegstein

    (University of California, San Francisco)

  • John L. Rubenstein

    (University of California, San Francisco)

  • Jose Manuel Garcia-Verdugo

    (CIBERNED)

  • Eric J. Huang

    (University of California, San Francisco)

  • Arturo Alvarez-Buylla

    (University of California, San Francisco
    University of California, San Francisco)

Abstract

The human amygdala grows during childhood, and its abnormal development is linked to mood disorders. The primate amygdala contains a large population of immature neurons in the paralaminar nuclei (PL), suggesting protracted development and possibly neurogenesis. Here we studied human PL development from embryonic stages to adulthood. The PL develops next to the caudal ganglionic eminence, which generates inhibitory interneurons, yet most PL neurons express excitatory markers. In children, most PL cells are immature (DCX+PSA-NCAM+), and during adolescence many transition into mature (TBR1+VGLUT2+) neurons. Immature PL neurons persist into old age, yet local progenitor proliferation sharply decreases in infants. Using single nuclei RNA sequencing, we identify the transcriptional profile of immature excitatory neurons in the human amygdala between 4–15 years. We conclude that the human PL contains excitatory neurons that remain immature for decades, a possible substrate for persistent plasticity at the interface of the hippocampus and amygdala.

Suggested Citation

  • Shawn F. Sorrells & Mercedes F. Paredes & Dmitry Velmeshev & Vicente Herranz-Pérez & Kadellyn Sandoval & Simone Mayer & Edward F. Chang & Ricardo Insausti & Arnold R. Kriegstein & John L. Rubenstein &, 2019. "Immature excitatory neurons develop during adolescence in the human amygdala," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10765-1
    DOI: 10.1038/s41467-019-10765-1
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-10765-1
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-10765-1?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10765-1. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.