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Bioinspired extracellular vesicles embedded with black phosphorus for molecular recognition-guided biomineralization

Author

Listed:
  • Yingqian Wang

    (Wuhan University)

  • Xiaoxia Hu

    (Wuhan University)

  • Lingling Zhang

    (Wuhan University
    Wuhan University)

  • Chunli Zhu

    (Wuhan University
    Hunan University)

  • Jie Wang

    (Wuhan University)

  • Yingxue Li

    (Wuhan University)

  • Yulan Wang

    (Wuhan University)

  • Can Wang

    (Wuhan University)

  • Yufeng Zhang

    (Wuhan University
    Wuhan University)

  • Quan Yuan

    (Wuhan University
    Hunan University)

Abstract

Extracellular vesicles (EVs) are involved in the regulation of cell physiological activity and the reconstruction of extracellular environment. Matrix vesicles (MVs) are a type of EVs released by bone-related functional cells, and they participate in the regulation of cell mineralization. Here, we report bioinspired MVs embedded with black phosphorus (BP) and functionalized with cell-specific aptamer (denoted as Apt-bioinspired MVs) for stimulating biomineralization. The aptamer can direct bioinspired MVs to targeted cells, and the increasing concentration of inorganic phosphate originating from BP can facilitate cell biomineralization. The photothermal effect of the Apt-bioinspired MVs can also promote the biomineralization process by stimulating the upregulated expression of heat shock proteins and alkaline phosphatase. In addition, the Apt-bioinspired MVs display outstanding bone regeneration performance. Our strategy provides a method for designing bionic tools to study the mechanisms of biological processes and advance the development of medical engineering.

Suggested Citation

  • Yingqian Wang & Xiaoxia Hu & Lingling Zhang & Chunli Zhu & Jie Wang & Yingxue Li & Yulan Wang & Can Wang & Yufeng Zhang & Quan Yuan, 2019. "Bioinspired extracellular vesicles embedded with black phosphorus for molecular recognition-guided biomineralization," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10761-5
    DOI: 10.1038/s41467-019-10761-5
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