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A neurotoxin that specifically targets Anopheles mosquitoes

Author

Listed:
  • Estefania Contreras

    (University of California)

  • Geoffrey Masuyer

    (Stockholm University)

  • Nadia Qureshi

    (University of California)

  • Swati Chawla

    (University of California)

  • Harpal S. Dhillon

    (University of California)

  • Han Lim Lee

    (Institute for Medical Research)

  • Jianwu Chen

    (University of California)

  • Pål Stenmark

    (Stockholm University
    Lund University)

  • Sarjeet S. Gill

    (University of California)

Abstract

Clostridial neurotoxins, including tetanus and botulinum neurotoxins, generally target vertebrates. We show here that this family of toxins has a much broader host spectrum, by identifying PMP1, a clostridial-like neurotoxin that selectively targets anopheline mosquitoes. Isolation of PMP1 from Paraclostridium bifermentans strains collected in anopheline endemic areas on two continents indicates it is widely distributed. The toxin likely evolved from an ancestral form that targets the nervous system of similar organisms, using a common mechanism that disrupts SNARE-mediated exocytosis. It cleaves the mosquito syntaxin and employs a unique receptor recognition strategy. Our research has an important impact on the study of the evolution of clostridial neurotoxins and provides the basis for the use of P. bifermentans strains and PMP1 as innovative, environmentally friendly approaches to reduce malaria through anopheline control.

Suggested Citation

  • Estefania Contreras & Geoffrey Masuyer & Nadia Qureshi & Swati Chawla & Harpal S. Dhillon & Han Lim Lee & Jianwu Chen & Pål Stenmark & Sarjeet S. Gill, 2019. "A neurotoxin that specifically targets Anopheles mosquitoes," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10732-w
    DOI: 10.1038/s41467-019-10732-w
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