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Mechanical impact of epithelial−mesenchymal transition on epithelial morphogenesis in Drosophila

Author

Listed:
  • Mélanie Gracia

    (Université de Toulouse, CNRS, UPS)

  • Sophie Theis

    (Université de Toulouse, CNRS, UPS
    Morphogénie Logiciels)

  • Amsha Proag

    (Université de Toulouse, CNRS, UPS)

  • Guillaume Gay

    (Morphogénie Logiciels)

  • Corinne Benassayag

    (Université de Toulouse, CNRS, UPS)

  • Magali Suzanne

    (Université de Toulouse, CNRS, UPS)

Abstract

Epithelial−mesenchymal transition (EMT) is an essential process both in physiological and pathological contexts. Intriguingly, EMT is often associated with tissue invagination during development; however, the impact of EMT on tissue remodeling remain unexplored. Here, we show that at the initiation of the EMT process, cells produce an apico-basal force, orthogonal to the surface of the epithelium, that constitutes an important driving force for tissue invagination in Drosophila. When EMT is ectopically induced, cells starting their delamination generate an orthogonal force and induce ectopic folding. Similarly, during mesoderm invagination, cells undergoing EMT generate an apico-basal force through the formation of apico-basal structures of myosin II. Using both laser microdissection and in silico physical modelling, we show that mesoderm invagination does not proceed if apico-basal forces are impaired, indicating that they constitute driving forces in the folding process. Altogether, these data reveal the mechanical impact of EMT on morphogenesis.

Suggested Citation

  • Mélanie Gracia & Sophie Theis & Amsha Proag & Guillaume Gay & Corinne Benassayag & Magali Suzanne, 2019. "Mechanical impact of epithelial−mesenchymal transition on epithelial morphogenesis in Drosophila," Nature Communications, Nature, vol. 10(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10720-0
    DOI: 10.1038/s41467-019-10720-0
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    Cited by:

    1. Aurélien Villedieu & Lale Alpar & Isabelle Gaugué & Amina Joudat & François Graner & Floris Bosveld & Yohanns Bellaïche, 2023. "Homeotic compartment curvature and tension control spatiotemporal folding dynamics," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Julien Fierling & Alphy John & Barthélémy Delorme & Alexandre Torzynski & Guy B. Blanchard & Claire M. Lye & Anna Popkova & Grégoire Malandain & Bénédicte Sanson & Jocelyn Étienne & Philippe Marmottan, 2022. "Embryo-scale epithelial buckling forms a propagating furrow that initiates gastrulation," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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