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A bed nucleus of stria terminalis microcircuit regulating inflammation-associated modulation of feeding

Author

Listed:
  • Yong Wang

    (University of Arizona
    Ministry of Education)

  • JungMin Kim

    (University of Arizona)

  • Matthew B. Schmit

    (University of Arizona
    University of Arizona)

  • Tiffany S. Cho

    (University of Arizona)

  • Caohui Fang

    (University of Arizona)

  • Haijiang Cai

    (University of Arizona
    University of Arizona)

Abstract

Loss of appetite or anorexia associated with inflammation impairs quality of life and increases morbidity in many diseases. However, the exact neural mechanism that mediates inflammation-associated anorexia is still poorly understood. Here we identified a population of neurons, marked by the expression of protein kinase C-delta, in the oval region of the bed nucleus of the stria terminalis (BNST), which are activated by various inflammatory signals. Silencing of these neurons attenuates the anorexia caused by these inflammatory signals. Our results demonstrate that these neurons mediate bidirectional control of general feeding behaviors. These neurons inhibit the lateral hypothalamus-projecting neurons in the ventrolateral part of BNST to regulate feeding, receive inputs from the canonical feeding regions of arcuate nucleus and parabrachial nucleus. Our data therefore define a BNST microcircuit that might coordinate canonical feeding centers to regulate food intake, which could offer therapeutic targets for feeding-related diseases such as anorexia and obesity.

Suggested Citation

  • Yong Wang & JungMin Kim & Matthew B. Schmit & Tiffany S. Cho & Caohui Fang & Haijiang Cai, 2019. "A bed nucleus of stria terminalis microcircuit regulating inflammation-associated modulation of feeding," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10715-x
    DOI: 10.1038/s41467-019-10715-x
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    Cited by:

    1. Takashi Nagashima & Suguru Tohyama & Kaori Mikami & Masashi Nagase & Mieko Morishima & Atsushi Kasai & Hitoshi Hashimoto & Ayako M. Watabe, 2022. "Parabrachial-to-parasubthalamic nucleus pathway mediates fear-induced suppression of feeding in male mice," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Anna J. Bowen & Y. Waterlily Huang & Jane Y. Chen & Jordan L. Pauli & Carlos A. Campos & Richard D. Palmiter, 2023. "Topographic representation of current and future threats in the mouse nociceptive amygdala," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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