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The role of PS 18:0/18:1 in membrane function

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  • Tore Skotland

    (Oslo University Hospital)

  • Kirsten Sandvig

    (Oslo University Hospital
    University of Oslo)

Abstract

Various studies have demonstrated that the two leaflets of cellular membranes interact, potentially through so-called interdigitation between the fatty acyl groups. While the molecular mechanism underlying interleaflet coupling remains to be fully understood, recent results suggest interactions between the very-long-chain sphingolipids in the outer leaflet, and phosphatidylserine PS18:0/18:1 in the inner leaflet, and an important role for cholesterol for these interactions. Here we review the evidence that cross-linking of sphingolipids may result in clustering of phosphatidylserine and transfer of signals to the cytosol. Although much remains to be uncovered, the molecular properties and abundance of PS 18:0/18:1 suggest a unique role for this lipid.

Suggested Citation

  • Tore Skotland & Kirsten Sandvig, 2019. "The role of PS 18:0/18:1 in membrane function," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10711-1
    DOI: 10.1038/s41467-019-10711-1
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    Cited by:

    1. Christine Linton & Jordan Wesolowski & Anna Lobley & Toshiyuki Yamaji & Kentaro Hanada & Fabienne Paumet, 2024. "Specialized contact sites regulate the fusion of chlamydial inclusion membranes," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Daniel P. Arnold & Yaxin Xu & Sho C. Takatori, 2023. "Antibody binding reports spatial heterogeneities in cell membrane organization," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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