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Identification of HIV transmitting CD11c+ human epidermal dendritic cells

Author

Listed:
  • Kirstie M. Bertram

    (The Westmead Institute for Medical Research
    The University of Sydney)

  • Rachel A. Botting

    (The Westmead Institute for Medical Research
    The University of Sydney
    Newcastle University)

  • Heeva Baharlou

    (The Westmead Institute for Medical Research
    The University of Sydney)

  • Jake W. Rhodes

    (The Westmead Institute for Medical Research
    The University of Sydney)

  • Hafsa Rana

    (The Westmead Institute for Medical Research
    The University of Sydney)

  • J. Dinny Graham

    (The Westmead Institute for Medical Research
    The University of Sydney)

  • Ellis Patrick

    (The Westmead Institute for Medical Research
    The University of Sydney)

  • James Fletcher

    (Newcastle University)

  • Toby M. Plasto

    (The Westmead Institute for Medical Research
    The University of Sydney)

  • Naomi R. Truong

    (The Westmead Institute for Medical Research
    The University of Sydney)

  • Caroline Royle

    (The Westmead Institute for Medical Research
    The University of Sydney)

  • Chloe M. Doyle

    (The Westmead Institute for Medical Research
    The University of Sydney)

  • Orion Tong

    (The Westmead Institute for Medical Research
    The University of Sydney)

  • Najla Nasr

    (The Westmead Institute for Medical Research
    The University of Sydney)

  • Laith Barnouti

    (Australia Plastic Surgery)

  • Mark P. Kohout

    (Australia Plastic Surgery)

  • Andrew J. Brooks

    (Westmead Hospital)

  • Michael P. Wines

    (Royal North Shore Hospital)

  • Peter Haertsch

    (Concord Repatriation General Hospital)

  • Jake Lim

    (Dr Jake Lim PLC)

  • Martijn P. Gosselink

    (The Westmead Institute for Medical Research
    Westmead Hospital)

  • Grahame Ctercteko

    (The Westmead Institute for Medical Research
    Westmead Hospital)

  • Jacob D. Estes

    (Leidos Biomedical Research Inc)

  • Melissa J. Churchill

    (RMIT University)

  • Paul U. Cameron

    (The Peter Doherty Institute for Infection and Immunity)

  • Eric Hunter

    (Emory Vaccine Center)

  • Muzlifah A. Haniffa

    (Newcastle University
    Newcastle Hospitals NHS Foundation Trust)

  • Anthony L. Cunningham

    (The Westmead Institute for Medical Research
    The University of Sydney)

  • Andrew N. Harman

    (The Westmead Institute for Medical Research
    The University of Sydney)

Abstract

Langerhans cells (LC) are thought to be the only mononuclear phagocyte population in the epidermis where they detect pathogens. Here, we show that CD11c+ dendritic cells (DCs) are also present. These cells are transcriptionally similar to dermal cDC2 but are more efficient antigen-presenting cells. Compared to LCs, epidermal CD11c+ DCs are enriched in anogenital tissues where they preferentially interact with HIV, express the higher levels of HIV entry receptor CCR5, support the higher levels of HIV uptake and replication and are more efficient at transmitting the virus to CD4 T cells. Importantly, these findings are observed using both a lab-adapted and transmitted/founder strain of HIV. We also describe a CD33low cell population, which is transcriptionally similar to LCs but does not appear to function as antigen-presenting cells or acts as HIV target cells. Our findings reveal that epidermal DCs in anogenital tissues potentially play a key role in sexual transmission of HIV.

Suggested Citation

  • Kirstie M. Bertram & Rachel A. Botting & Heeva Baharlou & Jake W. Rhodes & Hafsa Rana & J. Dinny Graham & Ellis Patrick & James Fletcher & Toby M. Plasto & Naomi R. Truong & Caroline Royle & Chloe M. , 2019. "Identification of HIV transmitting CD11c+ human epidermal dendritic cells," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10697-w
    DOI: 10.1038/s41467-019-10697-w
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