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Conformational manipulation of scale-up prepared single-chain polymeric nanogels for multiscale regulation of cells

Author

Listed:
  • Xiaoyu Chen

    (The Chinese University of Hong Kong)

  • Rui Li

    (The Chinese University of Hong Kong)

  • Siu Hong Dexter Wong

    (The Chinese University of Hong Kong)

  • Kongchang Wei

    (Laboratory for Biomimetic Membranes and Textiles)

  • Miao Cui

    (Beijing Genomic Institute-Shenzhen)

  • Huaijun Chen

    (Fudan University)

  • Yuanzhang Jiang

    (The Hong Kong Polytechnic University)

  • Boguang Yang

    (The Chinese University of Hong Kong)

  • Pengchao Zhao

    (The Chinese University of Hong Kong)

  • Jianbin Xu

    (Zhejiang University)

  • Heng Chen

    (Shenzhen University)

  • Chao Yin

    (The Chinese University of Hong Kong)

  • Sien Lin

    (The Chinese University of Hong Kong, Prince of Wales Hospital
    The Chinese University of Hong Kong)

  • Wayne Yuk-Wai Lee

    (The Chinese University of Hong Kong, Prince of Wales Hospital
    The Chinese University of Hong Kong)

  • Yihan Jing

    (The Chinese University of Hong Kong)

  • Zhen Li

    (Fudan University)

  • Zhengmeng Yang

    (The Chinese University of Hong Kong, Prince of Wales Hospital
    The Chinese University of Hong Kong)

  • Jiang Xia

    (The Chinese University of Hong Kong)

  • Guosong Chen

    (Fudan University)

  • Gang Li

    (The Chinese University of Hong Kong, Prince of Wales Hospital
    The Chinese University of Hong Kong)

  • Liming Bian

    (The Chinese University of Hong Kong
    The Chinese University of Hong Kong
    The Chinese University of Hong Kong
    China Orthopaedic Regenerative Medicine Group)

Abstract

Folded single chain polymeric nano-objects are the molecular level soft material with ultra-small size. Here, we report an easy and scalable method for preparing single-chain nanogels (SCNGs) with improved efficiency. We further investigate the impact of the dynamic molecular conformational change of SCNGs on cellular interactions from molecular to bulk scale. First, the supramolecular unfoldable SCNGs efficiently deliver siRNAs into stem cells as a molecular drug carrier in a conformation-dependent manner. Furthermore, the conformation changes of SCNGs enable dynamic and precise manipulation of ligand tether structure on 2D biomaterial interfaces to regulate the ligand–receptor ligation and mechanosensing of cells. Lastly, the dynamic SCNGs as the building blocks provide effective energy dissipation to bulk biomaterials such as hydrogels, thereby protecting the encapsulated stem cells from deleterious mechanical shocks in 3D matrix. Such a bottom-up molecular tailoring strategy will inspire further applications of single-chain nano-objects in the biomedical area.

Suggested Citation

  • Xiaoyu Chen & Rui Li & Siu Hong Dexter Wong & Kongchang Wei & Miao Cui & Huaijun Chen & Yuanzhang Jiang & Boguang Yang & Pengchao Zhao & Jianbin Xu & Heng Chen & Chao Yin & Sien Lin & Wayne Yuk-Wai Le, 2019. "Conformational manipulation of scale-up prepared single-chain polymeric nanogels for multiscale regulation of cells," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10640-z
    DOI: 10.1038/s41467-019-10640-z
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    Cited by:

    1. Zhengyu Xu & Jiajun Lu & Di Lu & Yiran Li & Hai Lei & Bin Chen & Wenfei Li & Bin Xue & Yi Cao & Wei Wang, 2024. "Rapidly damping hydrogels engineered through molecular friction," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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