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Neural effects of transcranial magnetic stimulation at the single-cell level

Author

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  • Maria C. Romero

    (Laboratorium voor Neuro- en Psychofysiologie, Katholieke Universiteit Leuven
    Onderzoeksgroep Bewegingscontrole & Neuroplasticiteit, Katholieke Universiteit Leuven
    Leuven Brain Institute, Katholieke Universiteit Leuven)

  • Marco Davare

    (Onderzoeksgroep Bewegingscontrole & Neuroplasticiteit, Katholieke Universiteit Leuven
    Leuven Brain Institute, Katholieke Universiteit Leuven)

  • Marcelo Armendariz

    (Laboratorium voor Neuro- en Psychofysiologie, Katholieke Universiteit Leuven
    Leuven Brain Institute, Katholieke Universiteit Leuven)

  • Peter Janssen

    (Laboratorium voor Neuro- en Psychofysiologie, Katholieke Universiteit Leuven
    Leuven Brain Institute, Katholieke Universiteit Leuven)

Abstract

Transcranial magnetic stimulation (TMS) can non-invasively modulate neural activity in humans. Despite three decades of research, the spatial extent of the cortical area activated by TMS is still controversial. Moreover, how TMS interacts with task-related activity during motor behavior is unknown. Here, we applied single-pulse TMS over macaque parietal cortex while recording single-unit activity at various distances from the center of stimulation during grasping. The spatial extent of TMS-induced activation is remarkably restricted, affecting the spiking activity of single neurons in an area of cortex measuring less than 2 mm in diameter. In task-related neurons, TMS evokes a transient excitation followed by reduced activity, paralleled by a significantly longer grasping time. Furthermore, TMS-induced activity and task-related activity do not summate in single neurons. These results furnish crucial experimental evidence for the neural effects of TMS at the single-cell level and uncover the neural underpinnings of behavioral effects of TMS.

Suggested Citation

  • Maria C. Romero & Marco Davare & Marcelo Armendariz & Peter Janssen, 2019. "Neural effects of transcranial magnetic stimulation at the single-cell level," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10638-7
    DOI: 10.1038/s41467-019-10638-7
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    Cited by:

    1. Alberto Lazari & Piergiorgio Salvan & Lennart Verhagen & Michiel Cottaar & Daniel Papp & Olof Jens van der Werf & Bronwyn Gavine & James Kolasinski & Matthew Webster & Charlotte J. Stagg & Matthew F. , 2022. "A macroscopic link between interhemispheric tract myelination and cortico-cortical interactions during action reprogramming," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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