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Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data

Author

Listed:
  • Dmitry Shungin

    (Umeå University
    Broad Institute of MIT and Harvard)

  • Simon Haworth

    (Medical Research Council Integrative Epidemiology Unit, Bristol Medical School
    Bristol Dental School)

  • Kimon Divaris

    (University of North Carolina
    University of North Carolina)

  • Cary S. Agler

    (University of North Carolina)

  • Yoichiro Kamatani

    (RIKEN Center for Integrative Medical Sciences)

  • Myoung Keun Lee

    (University of Pittsburgh)

  • Kelsey Grinde

    (University of Washington)

  • George Hindy

    (Lund University)

  • Viivi Alaraudanjoki

    (Research Unit of Oral Health Sciences University of Oulu)

  • Paula Pesonen

    (Faculty of Medicine, University of Oulu)

  • Alexander Teumer

    (University Medicine Greifswald)

  • Birte Holtfreter

    (and Preventive and Pediatric Dentistry University Medicine Greifswald)

  • Saori Sakaue

    (Osaka University Graduate School of Medicine)

  • Jun Hirata

    (Osaka University Graduate School of Medicine)

  • Yau-Hua Yu

    (Brigham and Women’s Hospital
    Tufts University School of Dental Medicine)

  • Paul M. Ridker

    (Brigham and Women’s Hospital
    Harvard Medical School)

  • Franco Giulianini

    (Brigham and Women’s Hospital)

  • Daniel I. Chasman

    (Brigham and Women’s Hospital
    Harvard Medical School)

  • Patrik K. E. Magnusson

    (Karolinska Instituet)

  • Takeaki Sudo

    (Graduate School of Medical and Dental Science of Tokyo Medical and Dental University)

  • Yukinori Okada

    (Osaka University Graduate School of Medicine)

  • Uwe Völker

    (University Medicine Greifswald)

  • Thomas Kocher

    (and Preventive and Pediatric Dentistry University Medicine Greifswald)

  • Vuokko Anttonen

    (Research Unit of Oral Health Sciences University of Oulu
    Oulu University Hospital and University of Oulu)

  • Marja-Liisa Laitala

    (Research Unit of Oral Health Sciences University of Oulu)

  • Marju Orho-Melander

    (Lund University)

  • Tamar Sofer

    (Harvard Medical School
    Brigham and Women’s Hospital)

  • John R. Shaffer

    (University of Pittsburgh
    University of Pittburgh
    University of Pittsburgh)

  • Alexandre Vieira

    (University of Pittsburgh)

  • Mary L. Marazita

    (University of Pittsburgh
    University of Pittburgh
    University of Pittsburgh)

  • Michiaki Kubo

    (RIKEN Center for Integrative Medical Sciences)

  • Yasushi Furuichi

    (Health Sciences University of Hokkaido)

  • Kari E. North

    (University of North Carolina)

  • Steve Offenbacher

    (University of North Carolina)

  • Erik Ingelsson

    (Stanford University School of Medicine
    Stanford University
    Stanford University)

  • Paul W. Franks

    (Genetic and Molecular Epidemiology Unit, Lund University
    Umeå University
    Harvard T. H. Chan School of Public Health)

  • Nicholas J. Timpson

    (Medical Research Council Integrative Epidemiology Unit, Bristol Medical School)

  • Ingegerd Johansson

    (Umeå University)

Abstract

Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then combine these in a genome-wide association study meta-analysis, identifying 47 novel and conditionally-independent risk loci for dental caries. We show that the heritability of dental caries is enriched for conserved genomic regions and partially overlapping with a range of complex traits including smoking, education, personality traits and metabolic measures. Using cardio-metabolic traits as an example in Mendelian randomization analysis, we estimate causal relationships and provide evidence suggesting that the processes contributing to dental caries may have undesirable downstream effects on health.

Suggested Citation

  • Dmitry Shungin & Simon Haworth & Kimon Divaris & Cary S. Agler & Yoichiro Kamatani & Myoung Keun Lee & Kelsey Grinde & George Hindy & Viivi Alaraudanjoki & Paula Pesonen & Alexander Teumer & Birte Hol, 2019. "Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10630-1
    DOI: 10.1038/s41467-019-10630-1
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    Cited by:

    1. Kimon Divaris & Gary D. Slade & Andrea G. Ferreira Zandona & John S. Preisser & Jeannie Ginnis & Miguel A. Simancas-Pallares & Cary S. Agler & Poojan Shrestha & Deepti S. Karhade & Apoena de Aguiar Ri, 2020. "Cohort Profile: ZOE 2.0—A Community-Based Genetic Epidemiologic Study of Early Childhood Oral Health," IJERPH, MDPI, vol. 17(21), pages 1-16, November.

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