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Electric field dynamics in the brain during multi-electrode transcranial electric stimulation

Author

Listed:
  • Ivan Alekseichuk

    (University of Minnesota)

  • Arnaud Y. Falchier

    (Nathan Kline Institute for Psychiatric Research)

  • Gary Linn

    (Nathan Kline Institute for Psychiatric Research)

  • Ting Xu

    (Child Mind Institute)

  • Michael P. Milham

    (Nathan Kline Institute for Psychiatric Research
    Child Mind Institute)

  • Charles E. Schroeder

    (Nathan Kline Institute for Psychiatric Research
    Columbia University College of Physicians and Surgeons)

  • Alexander Opitz

    (University of Minnesota)

Abstract

Neural oscillations play a crucial role in communication between remote brain areas. Transcranial electric stimulation with alternating currents (TACS) can manipulate these brain oscillations in a non-invasive manner. Recently, TACS using multiple electrodes with phase shifted stimulation currents were developed to alter long-range connectivity. Typically, an increase in coordination between two areas is assumed when they experience an in-phase stimulation and a disorganization through an anti-phase stimulation. However, the underlying biophysics of multi-electrode TACS has not been studied in detail. Here, we leverage direct invasive recordings from two non-human primates during multi-electrode TACS to characterize electric field magnitude and phase as a function of the phase of stimulation currents. Further, we report a novel “traveling wave” stimulation where the location of the electric field maximum changes over the stimulation cycle. Our results provide a mechanistic understanding of the biophysics of multi-electrode TACS and enable future developments of novel stimulation protocols.

Suggested Citation

  • Ivan Alekseichuk & Arnaud Y. Falchier & Gary Linn & Ting Xu & Michael P. Milham & Charles E. Schroeder & Alexander Opitz, 2019. "Electric field dynamics in the brain during multi-electrode transcranial electric stimulation," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10581-7
    DOI: 10.1038/s41467-019-10581-7
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