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Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters

Author

Listed:
  • Yong Gu Lee

    (Purdue University
    Purdue University)

  • Haiyan Chu

    (Endocyte Inc.)

  • Yingjuan Lu

    (Endocyte Inc.)

  • Christopher P. Leamon

    (Endocyte Inc.)

  • Madduri Srinivasarao

    (Purdue University
    Purdue University)

  • Karson S. Putt

    (Purdue University
    Purdue University)

  • Philip S. Low

    (Purdue University
    Purdue University)

Abstract

Although chimeric antigen receptor (CAR) T cell therapies have demonstrated considerable success in treating hematologic malignancies, they have simultaneously been plagued by a cytokine release syndrome (CRS) that can harm or even kill the cancer patient. We describe a CAR T cell strategy in which CAR T cell activation and cancer cell killing can be sensitively regulated by adjusting the dose of a low molecular weight adapter that must bridge between the CAR T cell and cancer cell to initiate tumor eradication. By controlling the concentration and dosing schedule of adapter administration, we document two methods that can rapidly terminate (

Suggested Citation

  • Yong Gu Lee & Haiyan Chu & Yingjuan Lu & Christopher P. Leamon & Madduri Srinivasarao & Karson S. Putt & Philip S. Low, 2019. "Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10565-7
    DOI: 10.1038/s41467-019-10565-7
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