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Layer-specific integration of locomotion and sensory information in mouse barrel cortex

Author

Listed:
  • Aslı Ayaz

    (University of Zurich
    University of Zurich and ETH Zurich)

  • Andreas Stäuble

    (University of Zurich
    University of Zurich and ETH Zurich)

  • Morio Hamada

    (University of Zurich
    University of Zurich and ETH Zurich)

  • Marie-Angela Wulf

    (University of Zurich and ETH Zurich
    University Hospital of Zurich)

  • Aman B. Saleem

    (University College London)

  • Fritjof Helmchen

    (University of Zurich
    University of Zurich and ETH Zurich)

Abstract

During navigation, rodents continually sample the environment with their whiskers. How locomotion modulates neuronal activity in somatosensory cortex, and how it is integrated with whisker-touch remains unclear. Here, we compared neuronal activity in layer 2/3 (L2/3) and L5 of barrel cortex using calcium imaging in mice running in a tactile virtual reality. Both layers increase their activity during running and concomitant whisking, in the absence of touch. Fewer neurons are modulated by whisking alone. Whereas L5 neurons respond transiently to wall-touch during running, L2/3 neurons show sustained activity. Consistently, neurons encoding running-with-touch are more abundant in L2/3 and they encode the run-speed better during touch. Few neurons across layers were also sensitive to abrupt perturbations of tactile flow during running. In summary, locomotion significantly enhances barrel cortex activity across layers with L5 neurons mainly reporting changes in touch conditions and L2/3 neurons continually integrating tactile stimuli with running.

Suggested Citation

  • Aslı Ayaz & Andreas Stäuble & Morio Hamada & Marie-Angela Wulf & Aman B. Saleem & Fritjof Helmchen, 2019. "Layer-specific integration of locomotion and sensory information in mouse barrel cortex," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10564-8
    DOI: 10.1038/s41467-019-10564-8
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    Cited by:

    1. Suma Chinta & Scott R. Pluta, 2023. "Neural mechanisms for the localization of unexpected external motion," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Rebecca J. Rabinovich & Daniel D. Kato & Randy M. Bruno, 2022. "Learning enhances encoding of time and temporal surprise in mouse primary sensory cortex," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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