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Induction of memory-like dendritic cell responses in vivo

Author

Listed:
  • Camaron R. Hole

    (The University of Texas at San Antonio
    The University of Texas at San Antonio)

  • Chrissy M. Leopold Wager

    (The University of Texas at San Antonio
    The University of Texas at San Antonio)

  • Natalia Castro-Lopez

    (The University of Texas at San Antonio
    The University of Texas at San Antonio)

  • Althea Campuzano

    (The University of Texas at San Antonio
    The University of Texas at San Antonio)

  • Hong Cai

    (The University of Texas at San Antonio
    The University of Texas at San Antonio)

  • Karen L. Wozniak

    (The University of Texas at San Antonio
    The University of Texas at San Antonio)

  • Yufeng Wang

    (The University of Texas at San Antonio
    The University of Texas at San Antonio)

  • Floyd L. Wormley

    (The University of Texas at San Antonio
    The University of Texas at San Antonio)

Abstract

Dendritic cells (DCs), a vital component of the innate immune system, are considered to lack antigen specificity and be devoid of immunological memory. Strategies that can induce memory-like responses from innate cells can be utilized to elicit protective immunity in immune deficient persons. Here we utilize an experimental immunization strategy to modulate DC inflammatory and memory-like responses against an opportunistic fungal pathogen that causes significant disease in immunocompromised individuals. Our results show that DCs isolated from protectively immunized mice exhibit enhanced transcriptional activation of interferon and immune signaling pathways. We also show long-term memory-like cytokine responses upon subsequent challenge with the fungal pathogen that are abrogated with inhibitors of specific histone modifications. Altogether, our study demonstrates that immunization strategies can be designed to elicit memory-like DC responses against infectious disease.

Suggested Citation

  • Camaron R. Hole & Chrissy M. Leopold Wager & Natalia Castro-Lopez & Althea Campuzano & Hong Cai & Karen L. Wozniak & Yufeng Wang & Floyd L. Wormley, 2019. "Induction of memory-like dendritic cell responses in vivo," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10486-5
    DOI: 10.1038/s41467-019-10486-5
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    Cited by:

    1. Xindi Gao & Yi Fu & Shengyi Sun & Tingyi Gu & Yanjian Li & Tianshu Sun & Hailong Li & Wei Du & Chenhao Suo & Chao Li & Yiru Gao & Yang Meng & Yue Ni & Sheng Yang & Tian Lan & Sixiang Sai & Jiayi Li & , 2022. "Cryptococcal Hsf3 controls intramitochondrial ROS homeostasis by regulating the respiratory process," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Diego Calzada-Fraile & Salvador Iborra & Marta Ramírez-Huesca & Inmaculada Jorge & Enrico Dotta & Elena Hernández-García & Noa Martín-Cófreces & Estanislao Nistal-Villán & Esteban Veiga & Jesús Vázque, 2023. "Immune synapse formation promotes lipid peroxidation and MHC-I upregulation in licensed dendritic cells for efficient priming of CD8+ T cells," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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