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Adiponectin receptor PAQR-2 signaling senses low temperature to promote C. elegans longevity by regulating autophagy

Author

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  • Yuan-Li Chen

    (School of Life Sciences, Yunnan University
    Kunming Medical University)

  • Jun Tao

    (School of Life Sciences, Yunnan University)

  • Pei-Ji Zhao

    (School of Life Sciences, Yunnan University)

  • Wei Tang

    (School of Life Sciences, Yunnan University)

  • Jian-Ping Xu

    (McMaster University)

  • Ke-Qin Zhang

    (School of Life Sciences, Yunnan University)

  • Cheng-Gang Zou

    (School of Life Sciences, Yunnan University)

Abstract

Temperature is a key factor for determining the lifespan of both poikilotherms and homeotherms. It is believed that animals live longer at lower body temperatures. However, the precise mechanism remains largely unknown. Here, we report that autophagy serves as a boost mechanism for longevity at low temperature in the nematode Caenorhabditis elegans. The adiponectin receptor AdipoR2 homolog PAQR-2 signaling detects temperature drop and augments the biosynthesis of two ω-6 polyunsaturated fatty acids, γ-linolenic acid and arachidonic acid. These two polyunsaturated fatty acids in turn initiate autophagy in the epidermis, delaying an age-dependent decline in collagen contents, and extending the lifespan. Our findings reveal that the adiponectin receptor PAQR-2 signaling acts as a regulator linking low temperature with autophagy to extend lifespan, and suggest that such a mechanism may be evolutionally conserved among diverse organisms.

Suggested Citation

  • Yuan-Li Chen & Jun Tao & Pei-Ji Zhao & Wei Tang & Jian-Ping Xu & Ke-Qin Zhang & Cheng-Gang Zou, 2019. "Adiponectin receptor PAQR-2 signaling senses low temperature to promote C. elegans longevity by regulating autophagy," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10475-8
    DOI: 10.1038/s41467-019-10475-8
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    Cited by:

    1. Daniel J. Ham & Anastasiya Börsch & Kathrin Chojnowska & Shuo Lin & Aurel B. Leuchtmann & Alexander S. Ham & Marco Thürkauf & Julien Delezie & Regula Furrer & Dominik Burri & Michael Sinnreich & Chris, 2022. "Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    2. Nan Wu & Yi-Cheng Ma & Xin-Qian Gong & Pei-Ji Zhao & Yong-Jian Jia & Qiu Zhao & Jia-Hong Duan & Cheng-Gang Zou, 2023. "The metabolite alpha-ketobutyrate extends lifespan by promoting peroxisomal function in C. elegans," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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