IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v10y2019i1d10.1038_s41467-019-10461-0.html
   My bibliography  Save this article

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Author

Listed:
  • Darina Czamara

    (Max-Planck-Institute of Psychiatry, Department of Translational Research in Psychiatry)

  • Gökçen Eraslan

    (German Research Center for Environmental Health
    Technische Universität München)

  • Christian M. Page

    (Oslo University Hospital
    Norwegian Institute of Public Health)

  • Jari Lahti

    (University of Helsinki
    University of Helsinki)

  • Marius Lahti-Pulkkinen

    (University of Helsinki
    University of Edinburgh)

  • Esa Hämäläinen

    (Helsinki University)

  • Eero Kajantie

    (Oulu University Hospital and University of Oulu, PEDEGO Research Unit
    University of Helsinki and Helsinki University Hospital
    National Institute for Health and Welfare)

  • Hannele Laivuori

    (Medical and Clinical Genetics and Obstetrics and Gynaecology University of Helsinki and Helsinki University Central Hospital
    University of Helsinki
    University of Tampere
    Tampere University Hospital)

  • Pia M. Villa

    (Medical and Clinical Genetics and Obstetrics and Gynaecology University of Helsinki and Helsinki University Central Hospital)

  • Rebecca M. Reynolds

    (University of Edinburgh)

  • Wenche Nystad

    (Norwegian Institute of Public Health)

  • Siri E. Håberg

    (Norwegian Institute of Public Health)

  • Stephanie J. London

    (Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services)

  • Kieran J. O’Donnell

    (Douglas Mental Health University Institute, McGill University
    Sackler Program for Epigenetics and Psychobiology at McGill University)

  • Elika Garg

    (Douglas Mental Health University Institute, McGill University)

  • Michael J. Meaney

    (Douglas Mental Health University Institute, McGill University
    Sackler Program for Epigenetics and Psychobiology at McGill University
    Singapore Institute for Clinical Sciences)

  • Sonja Entringer

    (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Medical Psychology
    University of California, Irvine, Development, Health, and Disease Research Program)

  • Pathik D. Wadhwa

    (University of California, Irvine, Development, Health, and Disease Research Program
    University of California, Irvine, School of Medicine)

  • Claudia Buss

    (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Medical Psychology
    University of California, Irvine, Development, Health, and Disease Research Program)

  • Meaghan J. Jones

    (University of British Columbia and the BC Children’s Hospital Research Institute)

  • David T. S. Lin

    (University of British Columbia and the BC Children’s Hospital Research Institute)

  • Julie L. MacIsaac

    (University of British Columbia and the BC Children’s Hospital Research Institute)

  • Michael S. Kobor

    (University of British Columbia and the BC Children’s Hospital Research Institute)

  • Nastassja Koen

    (University of Cape Town
    South African Medical Research Council (SAMRC), Unit on Risk and Resilience in Mental Disorders)

  • Heather J. Zar

    (University of Cape Town)

  • Karestan C. Koenen

    (Harvard T. H. Chan School of Public Health)

  • Shareefa Dalvie

    (University of Cape Town)

  • Dan J. Stein

    (University of Cape Town
    South African Medical Research Council (SAMRC), Unit on Risk and Resilience in Mental Disorders)

  • Ivan Kondofersky

    (German Research Center for Environmental Health
    Technische Universität München)

  • Nikola S. Müller

    (German Research Center for Environmental Health)

  • Fabian J. Theis

    (German Research Center for Environmental Health
    Technische Universität München)

  • Katri Räikkönen

    (University of Helsinki)

  • Elisabeth B. Binder

    (Max-Planck-Institute of Psychiatry, Department of Translational Research in Psychiatry
    Emory University School of Medicine)

Abstract

Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overall n = 2365). We use Akaike’s information criterion to test which factors best explain variability of methylation in the cohort-specific VMRs: several prenatal environmental factors (E), genotypes in cis (G), or their additive (G + E) or interaction (GxE) effects. Genetic and environmental factors in combination best explain DNAm at the majority of VMRs. The CpGs best explained by either G, G + E or GxE are functionally distinct. The enrichment of genetic variants from GxE models in GWAS for complex disorders supports their importance for disease risk.

Suggested Citation

  • Darina Czamara & Gökçen Eraslan & Christian M. Page & Jari Lahti & Marius Lahti-Pulkkinen & Esa Hämäläinen & Eero Kajantie & Hannele Laivuori & Pia M. Villa & Rebecca M. Reynolds & Wenche Nystad & Sir, 2019. "Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns," Nature Communications, Nature, vol. 10(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10461-0
    DOI: 10.1038/s41467-019-10461-0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-10461-0
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-10461-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Lucas Alvizi & Diogo Nani & Luciano Abreu Brito & Gerson Shigeru Kobayashi & Maria Rita Passos-Bueno & Roberto Mayor, 2023. "Neural crest E-cadherin loss drives cleft lip/palate by epigenetic modulation via pro-inflammatory gene–environment interaction," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Jacob Bergstedt & Sadoune Ait Kaci Azzou & Kristin Tsuo & Anthony Jaquaniello & Alejandra Urrutia & Maxime Rotival & David T. S. Lin & Julia L. MacIsaac & Michael S. Kobor & Matthew L. Albert & Darrag, 2022. "The immune factors driving DNA methylation variation in human blood," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10461-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.