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Monitoring biomolecule concentrations in tissue using a wearable droplet microfluidic-based sensor

Author

Listed:
  • Adrian M. Nightingale

    (University of Southampton)

  • Chi Leng Leong

    (University of Southampton
    Imperial College London, South Kensington)

  • Rachel A. Burnish

    (University Hospital Southampton NHS Foundation Trust)

  • Sammer-ul Hassan

    (University of Southampton)

  • Yu Zhang

    (University of Southampton)

  • Geraldine F. Clough

    (University of Southampton)

  • Martyn G. Boutelle

    (Imperial College London, South Kensington)

  • David Voegeli

    (University of Southampton
    University of Winchester)

  • Xize Niu

    (University of Southampton)

Abstract

Knowing how biomarker levels vary within biological fluids over time can produce valuable insight into tissue physiology and pathology, and could inform personalised clinical treatment. We describe here a wearable sensor for monitoring biomolecule levels that combines continuous fluid sampling with in situ analysis using wet-chemical assays (with the specific assay interchangeable depending on the target biomolecule). The microfluidic device employs a droplet flow regime to maximise the temporal response of the device, using a screw-driven push-pull peristaltic micropump to robustly produce nanolitre-sized droplets. The fully integrated sensor is contained within a small (palm-sized) footprint, is fully autonomous, and features high measurement frequency (a measurement every few seconds) meaning deviations from steady-state levels are quickly detected. We demonstrate how the sensor can track perturbed glucose and lactate levels in dermal tissue with results in close agreement with standard off-line analysis and consistent with changes in peripheral blood levels.

Suggested Citation

  • Adrian M. Nightingale & Chi Leng Leong & Rachel A. Burnish & Sammer-ul Hassan & Yu Zhang & Geraldine F. Clough & Martyn G. Boutelle & David Voegeli & Xize Niu, 2019. "Monitoring biomolecule concentrations in tissue using a wearable droplet microfluidic-based sensor," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10401-y
    DOI: 10.1038/s41467-019-10401-y
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    Cited by:

    1. Rutvik Lathia & Satchit Nagpal & Chandantaru Dey Modak & Satyarthi Mishra & Deepak Sharma & Bheema Sankar Reddy & Pavan Nukala & Ramray Bhat & Prosenjit Sen, 2023. "Tunable encapsulation of sessile droplets with solid and liquid shells," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Sitong Li & Rui Zhang & Guanghao Zhang & Luyizheng Shuai & Wang Chang & Xiaoyu Hu & Min Zou & Xiang Zhou & Baigang An & Dong Qian & Zunfeng Liu, 2022. "Microfluidic manipulation by spiral hollow-fibre actuators," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    3. Joana Krämer & Laura M. Grimm & Chunting Zhong & Michael Hirtz & Frank Biedermann, 2023. "A supramolecular cucurbit[8]uril-based rotaxane chemosensor for the optical tryptophan detection in human serum and urine," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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