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CHML promotes liver cancer metastasis by facilitating Rab14 recycle

Author

Listed:
  • Tian-Wei Chen

    (Chinese Academy of Sciences
    Chinese Academy of Sciences
    Fengxian Hospital Affiliated to Southern Medical University)

  • Fen-Fen Yin

    (Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Yan-Mei Yuan

    (Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Dong-Xian Guan

    (Chinese Academy of Sciences)

  • Erbin Zhang

    (Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Feng-Kun Zhang

    (Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Hao Jiang

    (Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Ning Ma

    (Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Jing-Jing Wang

    (Chinese Academy of Sciences)

  • Qian-Zhi Ni

    (Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Lin Qiu

    (Chinese Academy of Sciences)

  • Jing Feng

    (Fengxian Hospital Affiliated to Southern Medical University)

  • Xue-Li Zhang

    (Fengxian Hospital Affiliated to Southern Medical University)

  • Ying Bao

    (Huzhou University)

  • Kang Wang

    (Second Military Medical University)

  • Shu-Qun Cheng

    (Second Military Medical University)

  • Xiao-Fan Wang

    (Duke University Medical Center)

  • Xiang Wang

    (Huzhou University)

  • Jing-Jing Li

    (Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Dong Xie

    (Chinese Academy of Sciences
    Chinese Academy of Sciences
    China National Center for Food Safety Risk Assessment
    ShanghaiTech University)

Abstract

Metastasis-associated recurrence is the major cause of poor prognosis in hepatocellular carcinoma (HCC), however, the underlying mechanisms remain largely elusive. In this study, we report that expression of choroideremia-like (CHML) is increased in HCC, associated with poor survival, early recurrence and more satellite nodules in HCC patients. CHML promotes migration, invasion and metastasis of HCC cells, in a Rab14-dependent manner. Mechanism study reveals that CHML facilitates constant recycling of Rab14 by escorting Rab14 to the membrane. Furthermore, we identify several metastasis regulators as cargoes carried by Rab14-positive vesicles, including Mucin13 and CD44, which may contribute to metastasis-promoting effects of CHML. Altogether, our data establish CHML as a potential promoter of HCC metastasis, and the CHML-Rab14 axis may be a promising therapeutic target for HCC.

Suggested Citation

  • Tian-Wei Chen & Fen-Fen Yin & Yan-Mei Yuan & Dong-Xian Guan & Erbin Zhang & Feng-Kun Zhang & Hao Jiang & Ning Ma & Jing-Jing Wang & Qian-Zhi Ni & Lin Qiu & Jing Feng & Xue-Li Zhang & Ying Bao & Kang W, 2019. "CHML promotes liver cancer metastasis by facilitating Rab14 recycle," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10364-0
    DOI: 10.1038/s41467-019-10364-0
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