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Adipose HuR protects against diet-induced obesity and insulin resistance

Author

Listed:
  • Jingyuan Li

    (Qilu Hospital of Shandong University)

  • Li Gong

    (Qilu Hospital of Shandong University)

  • Shaozhuang Liu

    (Qilu Hospital of Shandong University)

  • Yujie Zhang

    (Qilu Hospital of Shandong University)

  • Chunmei Zhang

    (Qilu Hospital of Shandong University)

  • Mi Tian

    (Qilu Hospital of Shandong University)

  • Huixia Lu

    (Qilu Hospital of Shandong University)

  • Peili Bu

    (Qilu Hospital of Shandong University)

  • Jianmin Yang

    (Qilu Hospital of Shandong University)

  • Changhan Ouyang

    (Hubei University of Science and Technology)

  • Xiuxin Jiang

    (Qilu Hospital of Shandong University)

  • Jiliang Wu

    (Hubei University of Science and Technology)

  • Yun Zhang

    (Qilu Hospital of Shandong University)

  • Qing Min

    (Hubei University of Science and Technology)

  • Cheng Zhang

    (Qilu Hospital of Shandong University)

  • Wencheng Zhang

    (Qilu Hospital of Shandong University
    Hubei University of Science and Technology)

Abstract

Human antigen R (HuR) is a member of the Hu family of RNA-binding proteins and is involved in many physiological processes. Obesity, as a worldwide healthcare problem, has attracted more and more attention. To investigate the role of adipose HuR, we generate adipose-specific HuR knockout (HuRAKO) mice. As compared with control mice, HuRAKO mice show obesity when induced with a high-fat diet, along with insulin resistance, glucose intolerance, hypercholesterolemia and increased inflammation in adipose tissue. The obesity of HuRAKO mice is attributed to adipocyte hypertrophy in white adipose tissue due to decreased expression of adipose triglyceride lipase (ATGL). HuR positively regulates ATGL expression by promoting the mRNA stability and translation of ATGL. Consistently, the expression of HuR in adipose tissue is reduced in obese humans. This study suggests that adipose HuR may be a critical regulator of ATGL expression and lipolysis and thereby controls obesity and metabolic syndrome.

Suggested Citation

  • Jingyuan Li & Li Gong & Shaozhuang Liu & Yujie Zhang & Chunmei Zhang & Mi Tian & Huixia Lu & Peili Bu & Jianmin Yang & Changhan Ouyang & Xiuxin Jiang & Jiliang Wu & Yun Zhang & Qing Min & Cheng Zhang , 2019. "Adipose HuR protects against diet-induced obesity and insulin resistance," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10348-0
    DOI: 10.1038/s41467-019-10348-0
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    Cited by:

    1. Hongrui Wang & Liang Yu & Jin’e Wang & Yaqing Zhang & Mengchen Xu & Cheng Lv & Bing Cui & Mengmeng Yuan & Yu Zhang & Yupeng Yan & Rutai Hui & Yibo Wang, 2023. "SLC35D3 promotes white adipose tissue browning to ameliorate obesity by NOTCH signaling," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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