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Altered respiratory virome and serum cytokine profile associated with recurrent respiratory tract infections in children

Author

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  • Yanpeng Li

    (Chinese Academy of Sciences (CAS)
    Chinese Academy of Sciences)

  • Xuemin Fu

    (Chinese Academy of Sciences)

  • Jinmin Ma

    (BGI-Shenzhen)

  • Jianhui Zhang

    (Chinese Academy of Sciences (CAS))

  • Yihong Hu

    (Chinese Academy of Sciences)

  • Wei Dong

    (Shanghai Nanxiang Hospital, Jiading District)

  • Zhenzhou Wan

    (Medical Laboratory of Taizhou Fourth People’s Hospital)

  • Qiongfang Li

    (BGI-Shenzhen)

  • Yi-Qun Kuang

    (Henan University)

  • Ke Lan

    (Chinese Academy of Sciences
    Wuhan University)

  • Xia Jin

    (Chinese Academy of Sciences)

  • Jian-Hua Wang

    (Chinese Academy of Sciences)

  • Chiyu Zhang

    (Chinese Academy of Sciences (CAS)
    Chinese Academy of Sciences)

Abstract

Recurrent acute respiratory tract infections (ARTIs) affect a large population, yet the specific decisive factors are largely unknown. Here we study a population of 4407 children diagnosed with ARTI, comparing respiratory virome and serum cytokine profiles associated with multiple ARTIs and single ARTI during a six-year period. The relative abundance of Propionibacterium phages is significantly elevated in multiple ARTIs compared to single ARTI group. Serum levels of TIMP-1 and PDGF-BB are markedly increased in multiple ARTIs compared to single-ARTI and non-ARTI controls, making these two cytokines potential predictors for multiple ARTIs. The presence of Propionibacterium phages is associated with higher levels of TIMP-1 and PDGF-BB. Receiver operating characteristic (ROC) curve analyses show that the combination of TIMP-1, PDGF-BB and Propionibacterium phages could be a strong predictor for multiple ARTIs. These findings indicate that respiratory microbe homeostasis and specific cytokines are associated with the onset of multiple ARTIs over time.

Suggested Citation

  • Yanpeng Li & Xuemin Fu & Jinmin Ma & Jianhui Zhang & Yihong Hu & Wei Dong & Zhenzhou Wan & Qiongfang Li & Yi-Qun Kuang & Ke Lan & Xia Jin & Jian-Hua Wang & Chiyu Zhang, 2019. "Altered respiratory virome and serum cytokine profile associated with recurrent respiratory tract infections in children," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10294-x
    DOI: 10.1038/s41467-019-10294-x
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