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DNA-templated synthesis of biomimetic cell wall for nanoencapsulation and protection of mammalian cells

Author

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  • Peng Shi

    (The Pennsylvania State University, University Park)

  • Nan Zhao

    (The Pennsylvania State University, University Park)

  • James Coyne

    (The Pennsylvania State University, University Park)

  • Yong Wang

    (The Pennsylvania State University, University Park)

Abstract

Mammalian cells are different from plant and microbial cells, having no exterior cell walls for protection. Environmental assaults can easily damage or destroy mammalian cells. Thus, the ability to develop a biomimetic cell wall (BCW) on their plasma membrane as a shield can advance various applications. Here we demonstrate the synthesis of BCW with a framing template and a crosslinked matrix for shielding live mammalian cells. The framing template is a supramolecular DNA structure. The crosslinked matrix is a polyelectrolyte complex made of alginate and polylysine. As the entire procedure of BCW synthesis is strictly operated under physiological conditions, BCW-covered mammalian cells can maintain high bioactivity. More importantly, the data show that BCW can shield live mammalian cells from not only physical assaults but also biological assaults. Thus, this study has successfully demonstrated the synthesis of BCW on live mammalian cells with great potential of shielding them from environmental assaults.

Suggested Citation

  • Peng Shi & Nan Zhao & James Coyne & Yong Wang, 2019. "DNA-templated synthesis of biomimetic cell wall for nanoencapsulation and protection of mammalian cells," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10231-y
    DOI: 10.1038/s41467-019-10231-y
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    Cited by:

    1. Wenjing Jin & Xianfeng Lin & Haihua Pan & Chenchen Zhao & Pengcheng Qiu & Ruibo Zhao & Zihe Hu & Yanyan Zhou & Haiyan Wu & Xiao Chen & Hongwei Ouyang & Zhijian Xie & Ruikang Tang, 2021. "Engineered osteoclasts as living treatment materials for heterotopic ossification therapy," Nature Communications, Nature, vol. 12(1), pages 1-12, December.

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