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Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy

Author

Listed:
  • Carlota Dobaño

    (ISGlobal, Hospital Clínic - Universitat de Barcelona
    Centro de Investigação em Saúde de Manhiça (CISM))

  • Hèctor Sanz

    (ISGlobal, Hospital Clínic - Universitat de Barcelona)

  • Hermann Sorgho

    (Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé)

  • David Dosoo

    (Kintampo Health Research Centre)

  • Maximilian Mpina

    (Ifakara Health Institute, Bagamoyo Research and Training Centre
    Swiss Tropical and Public Health Institute
    University of Basel)

  • Itziar Ubillos

    (ISGlobal, Hospital Clínic - Universitat de Barcelona)

  • Ruth Aguilar

    (ISGlobal, Hospital Clínic - Universitat de Barcelona)

  • Tom Ford

    (IAVI - Human Immunology Laboratory, Imperial College)

  • Núria Díez-Padrisa

    (ISGlobal, Hospital Clínic - Universitat de Barcelona)

  • Nana Aba Williams

    (ISGlobal, Hospital Clínic - Universitat de Barcelona)

  • Aintzane Ayestaran

    (ISGlobal, Hospital Clínic - Universitat de Barcelona)

  • Ousmane Traore

    (Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé)

  • Augusto J. Nhabomba

    (Centro de Investigação em Saúde de Manhiça (CISM))

  • Chenjerai Jairoce

    (Centro de Investigação em Saúde de Manhiça (CISM))

  • John Waitumbi

    (Walter Reed Army Institute of Research/Kenya Medical Research Institute)

  • Selidji Todagbe Agnandji

    (Centre de Recherches Médicales de Lambaréné (CERMEL)
    University of Tübingen)

  • Simon Kariuki

    (Kenya Medical Research Institute/Centre for Global Health)

  • Salim Abdulla

    (Ifakara Health Institute, Bagamoyo Research and Training Centre)

  • John J. Aponte

    (ISGlobal, Hospital Clínic - Universitat de Barcelona
    Centro de Investigação em Saúde de Manhiça (CISM))

  • Benjamin Mordmüller

    (University of Tübingen)

  • Kwaku Poku Asante

    (Kintampo Health Research Centre)

  • Seth Owusu-Agyei

    (Kintampo Health Research Centre)

  • Halidou Tinto

    (Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé)

  • Joseph J. Campo

    (ISGlobal, Hospital Clínic - Universitat de Barcelona
    Centro de Investigação em Saúde de Manhiça (CISM))

  • Gemma Moncunill

    (ISGlobal, Hospital Clínic - Universitat de Barcelona
    Centro de Investigação em Saúde de Manhiça (CISM))

  • Ben Gyan

    (Kintampo Health Research Centre
    University of Ghana)

  • Clarissa Valim

    (Michigan State University
    Harvard T.H. Chen School of Public Health
    Boston University)

  • Claudia Daubenberger

    (Swiss Tropical and Public Health Institute
    University of Basel)

Abstract

RTS,S/AS01E has been tested in a phase 3 malaria vaccine study with partial efficacy in African children and infants. In a cohort of 1028 subjects from one low (Bagomoyo) and two high (Nanoro, Kintampo) malaria transmission sites, we analysed IgG plasma/serum concentration and avidity to CSP (NANP-repeat and C-terminal domains) after a 3-dose vaccination against time to clinical malaria events during 12-months. Here we report that RTS,S/AS01E induces substantial increases in IgG levels from pre- to post-vaccination (p

Suggested Citation

  • Carlota Dobaño & Hèctor Sanz & Hermann Sorgho & David Dosoo & Maximilian Mpina & Itziar Ubillos & Ruth Aguilar & Tom Ford & Núria Díez-Padrisa & Nana Aba Williams & Aintzane Ayestaran & Ousmane Traore, 2019. "Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10195-z
    DOI: 10.1038/s41467-019-10195-z
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