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The viral protein corona directs viral pathogenesis and amyloid aggregation

Author

Listed:
  • Kariem Ezzat

    (Stockholm University
    Karolinska Institutet)

  • Maria Pernemalm

    (Science for Life Laboratory and Karolinska Institutet)

  • Sandra Pålsson

    (Stockholm University)

  • Thomas C. Roberts

    (University of Oxford
    Sanford Burnham Prebys Medical Discovery Institute, Development, Aging and Regeneration Program)

  • Peter Järver

    (Stockholm University)

  • Aleksandra Dondalska

    (Stockholm University)

  • Burcu Bestas

    (Karolinska Institutet
    Discovery Sciences, R&D Biopharmaceuticals, AstraZeneca)

  • Michal J. Sobkowiak

    (Karolinska University Hospital Huddinge)

  • Bettina Levänen

    (Karolinska Institutet)

  • Magnus Sköld

    (Karolinska Institutet
    Karolinska University Hospital)

  • Elizabeth A. Thompson

    (Karolinska Institutet)

  • Osama Saher

    (Karolinska Institutet
    Cairo University)

  • Otto K. Kari

    (University of Helsinki)

  • Tatu Lajunen

    (University of Helsinki)

  • Eva Sverremark Ekström

    (Stockholm University)

  • Caroline Nilsson

    (Karolinska Institutet and Sachs’ Children and Youth Hospital)

  • Yevheniia Ishchenko

    (University of Eastern Finland)

  • Tarja Malm

    (University of Eastern Finland)

  • Matthew J. A. Wood

    (University of Oxford)

  • Ultan F. Power

    (Queens’ University Belfast)

  • Sergej Masich

    (Karolinska Institutet)

  • Anders Lindén

    (Karolinska Institutet
    Karolinska University Hospital)

  • Johan K. Sandberg

    (Karolinska University Hospital Huddinge)

  • Janne Lehtiö

    (Science for Life Laboratory and Karolinska Institutet)

  • Anna-Lena Spetz

    (Stockholm University)

  • Samir EL Andaloussi

    (Karolinska Institutet
    University of Oxford
    Evox Therapeutics Limited, Oxford Science Park)

Abstract

Artificial nanoparticles accumulate a protein corona layer in biological fluids, which significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses share many biophysical properties with artificial nanoparticles in extracellular environments and here we show that respiratory syncytial virus (RSV) and herpes simplex virus type 1 (HSV-1) accumulate a rich and distinctive protein corona in different biological fluids. Moreover, we show that corona pre-coating differentially affects viral infectivity and immune cell activation. In addition, we demonstrate that viruses bind amyloidogenic peptides in their corona and catalyze amyloid formation via surface-assisted heterogeneous nucleation. Importantly, we show that HSV-1 catalyzes the aggregation of the amyloid β-peptide (Aβ42), a major constituent of amyloid plaques in Alzheimer’s disease, in vitro and in animal models. Our results highlight the viral protein corona as an acquired structural layer that is critical for viral–host interactions and illustrate a mechanistic convergence between viral and amyloid pathologies.

Suggested Citation

  • Kariem Ezzat & Maria Pernemalm & Sandra Pålsson & Thomas C. Roberts & Peter Järver & Aleksandra Dondalska & Burcu Bestas & Michal J. Sobkowiak & Bettina Levänen & Magnus Sköld & Elizabeth A. Thompson , 2019. "The viral protein corona directs viral pathogenesis and amyloid aggregation," Nature Communications, Nature, vol. 10(1), pages 1-16, December.
  • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-10192-2
    DOI: 10.1038/s41467-019-10192-2
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    Cited by:

    1. Taniya Bhardwaj & Kundlik Gadhave & Shivani K. Kapuganti & Prateek Kumar & Zacharias Faidon Brotzakis & Kumar Udit Saumya & Namyashree Nayak & Ankur Kumar & Richa Joshi & Bodhidipra Mukherjee & Aparna, 2023. "Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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